去甲肾上腺素转运蛋白抗体（神经递质去甲肾上腺素转运体）Anti-NET1/Noradrenaline transporter的产品详细说明：

－－产品介绍：Catecholamine, a term used for the hormone adrenaline ａnd its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings ａnd exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness ａnd arousal, both cognitive ａnd non-cognitive expression of behaviors, ａnd control of the endocrine ａnd autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings ａnd has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals is reabsorbed （70-90%） by noradrenaline transporters ａnd its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants ａnd psychostimulants, ａnd are deficient in affective ａnd autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons ａnd dendrites, ａnd hippocampus ａnd cortex, but is absent from epinephrine- ａnd dopamine-containing neurons. At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake ａnd concentrations in cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters ａnd several psychiatric ａnd cardiovascular disorders is just emerging. Recently, a single amino acid mutation （hNET-A457P） showed deficiency in noradrenaline transport in an orthostatic intolerance patient. Noradrenaline transporter protein consists of 617 amino acids ａnd has 12 trans-membrane domains, a characteristic feature of many membrane associated solute transporters.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Widely expressed.Similarity : Contains 1 DH （DBL-homology） domain.Contains 1 PH domain.Subunit : Interacts with RHOA in its GTP- ａnd GDP-bound states, ａnd with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1.

（1mg/1ml去甲肾上腺素转运蛋白抗体（神经递质去甲肾上腺素转运体）Anti-NET1/Noradrenaline transporter，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－去甲肾上腺素转运蛋白抗体（神经递质去甲肾上腺素转运体）的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, hrs, dog, cow, chk
产品类型：一抗
研究领域：心血管细胞生物神经生物学信号转导转录调节因子转运蛋白
蛋白分子量：predicted molecular weight: 70-80kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human NET1
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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