磷酸化核糖体p70 S6蛋白激酶抗体Anti-p-p70 S6 kinase alpha的产品详细说明：

－－产品介绍：In studies to elucidate key regulatory pathways in signal transduction, several protein serine/threonine （Ser/Thr） kinases have been identified. Included among such kinases are two distinct families of 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells, designated p70 S6 kinase ａnd p90 Rsk kinase. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured cells followed by activation of p70 S6 kinase. Both enzymes are regulated by serine/threonine phosphorylation, suggesting that specific kinases may exist upstream in the signaling pathway that regulate these kinases. In fact, evidence suggests that one such family of activating enzymes includes the members of the ERK MAP kinase family. The ERK MAP kinases are, in turn, regulated by phosphorylation at threonine ａnd tyrosine residues by a protein kinase designated MEK.Subcellular Location : Cell junction, synapse, synaptosome. Mitochondrion outer membrane. Isoform Alpha I: Nucleus. Cytoplasm. Isoform Alpha II: Cytoplasm.Tissue Specificity : Widely expressed.Similarity : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Subunit : Interacts with PPP1R9A/neurabin-1.

（1mg/1ml磷酸化核糖体p70 S6蛋白激酶抗体Anti-p-p70 S6 kinase alpha，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－磷酸化核糖体p70 S6蛋白激酶抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat
产品类型：一抗磷酸化抗体
研究领域：肿瘤细胞生物染色质和核信号信号转导细胞凋亡激酶和磷酸酶线粒体
蛋白分子量：predicted molecular weight: 70kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human p-p70 S6 kinase alpha
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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