铁调节蛋白25抗体Anti-Hepcidin-25的产品详细说明：

－－产品介绍：Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption ａnd iron storage in macrophages.Has strong antimicrobial activity against E.coli ML35P N.cinerea ａnd weaker against S.epidermidis, S.aureus ａnd group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.Tissue specificity: Highest expression in liver ａnd to a lesser extent in heart ａnd brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland ａnd thyroid gland. Secreted into the urine.Hepcidin是一种由肝脏细胞产生的具有广谱杀菌抑菌作用的抗菌肽，属于防御性蛋白家族。Hepcidin在肝脏合成时，首先产生一种早期多肽，由84个氨基酸残基组成。在其Gly24和Ser25之间存在一个酶切位点，当酶切去除其24个氨基酸残基的信号肽后，形成由60个氨基酸残基组成的前体肽（pro-Hepcidin），并通过转运进入血液循环，由前肽转化酶（propeptide convertase）在N端的不同位点剪接生成3种不同的成熟小肽，分别由20、22、25个氨基酸组成，其中以25个氨基酸为其主要形式和主要活性部分，称作Hepcidin-25。含有25个氨基酸的小分子多肽蛋白主要在肝脏表达，其中有8个半胱氨酸－－-含25个氨基酸的小分子多肽蛋白是活性片段,和许多富含半胱的抗菌肽类似具有显著的抗菌作用。经研究表明Hepcidin25是机体铁稳态调控途径中关键性效应分子,其主要生物学功能在于调节小肠细胞对铁的吸收，也有学者称为：抗菌肽Hepcidin25。由于该蛋白多肽中有多个半胱氨酸构成，故导致二硫键的形成－－-形成多聚体蛋白，其分子量在20-32kDa。

（1mg/1ml铁调节蛋白25抗体Anti-Hepcidin-25，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－铁调节蛋白25抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat
产品类型：一抗
研究领域：心血管细胞生物信号转导
蛋白分子量：predicted molecular weight: 20-32kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from hu Hepcidin-25
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

上海田源专业销售铁调节蛋白25抗体抗体产品，详细抗体目录请访问：http://www.app17.com/c68810/products/t87312.html