磷酸化周期素依赖性激酶5抗体Anti-phospho-CDK5（Tyr15）的产品详细说明：

－－产品介绍：CDK5 （Cyclin Dependent Kinase 5） is serine/threonine kinase involved in synaptic regulation ａnd neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression. CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, ａnd ovary. Its activity is detected almost exclusively in brain extracts. Neuronal ａnd muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 ａnd D3 type G1 cyclins ａnd can phosphorylate histone H1, TAU, MAP2 ａnd NF-H ａnd NF-M. Cdk5 activity is involved in terminal differentiation of neurons ａnd muscle cells.细胞周期素依赖性激酶-5属于小丝氨酸／苏氨酸周期素依赖性激酶家族成员，虽与其他成员序列具有同源性，但功能却不一样，即与细胞周期关系不大，却在中枢神经系统的发育和神经元正常功能的维持中发挥重要作用，并与一些退行性疾病及药物成瘾有密切联系。CDK-5是神经系统中重要的蛋白激酶,周期素依赖性激酶5在神经系统发育过程中,可调节轴突生长、神经元分化及迁移.*近研究表明,周期素依赖性激酶5激酶活性失调与阿尔茨海默病的发病有关.

（1mg/1ml磷酸化周期素依赖性激酶5抗体Anti-phospho-CDK5（Tyr15），的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－磷酸化周期素依赖性激酶5抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, rat, mo
产品类型：一抗磷酸化抗体
研究领域：肿瘤细胞生物神经生物学信号转导细胞周期蛋白转录调节因子激酶和磷酸酶
蛋白分子量：predicted molecular weight: 32kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from hu phospho-CDK5（Tyr15）
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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