组氨酸tRNA连接酶抗体Anti-HARS的产品详细说明：

－－产品介绍：Histidyl-tRNA synthetase （HisRS, Jo-1） is an aminoacyl-tRNA synthetase that charges transfer RNAs （tRNAs） with a cognate histidine residue to produce histidyl-tRNA. Histidyl-tRNA is essential for the incorporation of histidine into proteins （2）. Systemic autoimmune diseases lead to aminoacyl-tRNA synthetase autoantibodies that are directed against self structures. HisRS is an antigen in systemic autoimmune diseases such as rheumatic arthritis or polymyositis with associated interstitial lung disease, thrombocytopenia ａnd Raynaud’s phenomenon （vasospastic attacks that cause blood vessels to constrict） （3-5）. HisRS autoantibodies are unlike anti-synthetase antibodies because they bind the nonlinear, exposed epitopes on native HisRS when the enzyme is complexed to tRNA（His）Subcellular Location : Cytoplasmic

（1mg/1ml组氨酸tRNA连接酶抗体Anti-HARS，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－组氨酸tRNA连接酶抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat
产品类型：一抗
研究领域：细胞生物免疫学表观遗传学
蛋白分子量：predicted molecular weight: 56kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from hu HARS
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1:20-100IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

上海田源专业销售组氨酸tRNA连接酶抗体抗体产品，详细抗体目录请访问：http://www.chem17.com/st233816/erlist_675408.html