半胱氨酸蛋白酶8抗体Anti-caspase-8 subunit p18的产品详细说明：

－－产品介绍：Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A ａnd mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex （DISC）, which activates caspase-8. The actived protein is released from the complex ａnd further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits （p18 ａnd p10）, is widely expressed, but is detected at highest levels in peripheral blood leukocytes （PBLs）, thymus, liver ａnd spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D （caspase-8 deficiency disorder）, which is characterized by splenomegaly ａnd CD95-induced apoptosis of PBLs, ａnd may lead to immunodeficiency due to defects in T lymphocyte, NK cell ａnd B lymphocyte activation.Subcellular Location : Cytoplasm.Tissue Specificity : Isoform 1, isoform 5 ａnd isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus ａnd liver. Barely detectable in brain, testis ａnd skeletal muscle.Similarity : Belongs to the peptidase C14A family.Contains 2 DED （death effector） domains.Subunit : Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa （p18） ａnd a 10 kDa （p10） subunit. Interacts with FADD, CFLAR ａnd PEA15. Isoform 9 interacts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1. Interacts with TNFAIP8L2.

（1mg/1ml半胱氨酸蛋白酶8抗体Anti-caspase-8 subunit p18，的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

－－半胱氨酸蛋白酶8抗体的参数标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat
产品类型：一抗
研究领域：细胞生物免疫学神经生物学细胞凋亡
蛋白分子量：predicted molecular weight: 18/48kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human caspase-8 subunit p18
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

上海田源专业销售半胱氨酸蛋白酶8抗体抗体产品，详细抗体目录请访问：http://www.chem17.com/st233816/erlist_675408.html