磷酸化RNA聚合酶II CTD抗体Anti-RNA polymerase II CTD repeat YSPTSPS （phospho S2）360TIYO-上海田源公司

性能参数：

中文名称：磷酸化RNA聚合酶II CTD抗体 英文名称：Anti-RNA polymerase II CTD repeat YSPTSPS （phospho S2） 别名：POLR2A; POLR2; DNA directed RNA polymerase II A; DNA-directed RNA polymerase II largest su... 产品货号： 包装号：G320 产地：中国大陆/进口产品 商标/品牌：TIUE、TIYO、新试剂、田源试剂 供应商：上海田源试剂、新试剂

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产品详细描述

产品介绍：DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest ａnd catalytic component of RNA polymerase II which synthesizes mRNA precursors ａnd many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open ａnd close the cleft ａnd the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 ａnd crosses the cleft near the catalytic site ａnd is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain （CTD） of Pol II largest subunit （RPB1）, which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination ａnd mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate ａnd transcriptase for the viral RNA circular genome.

（1mg/1ml磷酸化RNA聚合酶II CTD抗体Anti-RNA polymerase II CTD repeat YSPTSPS （phospho S2），POLR2A; POLR2; DNA directed RNA polymerase II A; DNA-directed RNA polymerase II largest su...的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

磷酸化RNA聚合酶II CTD抗体的质量标准：

浓度：1mg/1ml 交叉反应：hu, mo, rat, dog, cow 产品类型：一抗磷酸化抗体 研究领域：信号转导转录调节因子表观遗传学 蛋白分子量：predicted molecular weight: 217kDa 性状：Lyophilized or Liquid 免疫原：KLH conjugated Synthesised phosphopeptide derived from human RNA polymerase II RPB1 around Y（p-S）PTSPS 亚型：polyclonal 纯化方法：affinity purified by Protein A 储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化RNA聚合酶II CTD抗体Anti-RNA polymerase II CTD repeat YSPTSPS （phospho S2）的相关产品目录：

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