软骨蛋白聚糖抗体Anti-Aggrecanase-2/ADAMTS-5
360TIYO-上海田源公司

性能参数：

中文名称：软骨蛋白聚糖抗体
英文名称：Anti-Aggrecanase-2/ADAMTS-5
别名：A disintegrin ａnd metalloproteinase with thrombospondin motifs 5; A disintegrin like ａnd m...
产品货号：
包装号：G320
产地：中国大陆/进口产品
商标/品牌：TIUE、TIYO、新试剂、田源试剂
供应商：上海田源试剂、新试剂
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产品详细描述

产品介绍：ADAMTS5 was first described as ADAMTS5, a protein elevated in mice during the peri-implantion period. At the same time, another group identified Aggrecanase 11, a protein elevated in arthritic synovium. The name was later changed to ADAMTS5. ADAMTS5 is expressed in human ａnd mouse. It has been found in heart, lung, cervix, uterus, ovary, brain, cartilage, ａnd numerous other tissues, as well as chondroblastoma cell lines. Initial observations indicated a role for ADAMTS5 in aggrecan cleavage ａnd cartilage destruction, especially in arthritis, ａnd potentially a role in embryo implantation. ADAMTS5 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, ａnd has been shown to efficiently cleave Aggrecan. In addition to the metalloprotease domain, ADAMTS5 has a propeptide domain, a prohormone convertase （PC, furin） cleavage site, a cysteine-rich domain, a spacer domain, ａnd two thrombospondin-1 like domains. ADAMTS5 is inhibited by the endogenous MMP inhibitors （TIMP1, 2, 3, ａnd 4） but most efficiently by TIMP3. Unlike many of the ADAMs proteases, ADAMTS5 does not have a transmembrane domain, ａnd is a secreted protein. Full length ADAMTS5 is a 930 amino acid protein with a predicted molecular mass is 101.7 kDa, but glycosylation ａnd the abundance of cysteine residues gives ADAMTS5 a greater apparent molecular weight on reduced SDS PAGE gels. When ADAMTS5 is secreted, it is cleaved at the furin cleavage site （predicted molecular mass 73.2 kDa） ａnd then further cleaved to generate a range of smaller forms.

软骨蛋白聚糖抗体的质量标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, pig, Rb, hrs, cow, dog
产品类型：一抗
研究领域：肿瘤免疫学激酶和磷酸酶
蛋白分子量：predicted molecular weight: 102kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human Aggrecan 2
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
产品应用：ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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（1mg/1ml软骨蛋白聚糖抗体Anti-Aggrecanase-2/ADAMTS-5，A disintegrin ａnd metalloproteinase with thrombospondin motifs 5; A disintegrin like ａnd m...的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

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