钙激活钾通道蛋白β1抗体Anti-KCNMB1/Maxi Potassium channel betaMaxiK channels are large conductance, voltage ａnd calcium-sensitive potassium channels whi...
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中文名称：钙激活钾通道蛋白β1抗体
英文名称：Anti-KCNMB1/Maxi Potassium channel beta
别名：MaxiK channels are large conductance, voltage ａnd calcium-sensitive potassium channels whi...
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable ａnd non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel （Maxi K+）. Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium ａnd by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor ａnd an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow ａnd blood pressure regulation. Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus ａnd corpus callosum.Similarity : Belongs to the KCNMB （TC 8.A.14.1） family. KCNMB1 subfamily.

钙激活钾通道蛋白β1抗体的质量标准：
浓度：1mg/1ml
交叉反应：hu, mo, rat, pig, hrs, cow, shp
产品类型：一抗
研究领域：心血管细胞生物神经生物学信号转导通道蛋白
蛋白分子量：predicted molecular weight: 21kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human KCNMB1
亚型：polyclonal
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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钙激活钾通道蛋白β1抗体Anti-KCNMB1/Maxi Potassium channel beta的相关产品目录：



（1mg/1ml钙激活钾通道蛋白β1抗体Anti-KCNMB1/Maxi Potassium channel beta，MaxiK channels are large conductance, voltage ａnd calcium-sensitive potassium channels whi...的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

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