维甲酸调节核基质相关蛋白Anti-RAMP/CDT2Lethal（2） denticleless protein homolog;CDW1;CDW1;DCAF2;DDB1 ａnd CUL4 associated fa...
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性能参数：

中文名称：维甲酸调节核基质相关蛋白
英文名称：Anti-RAMP/CDT2
别名：Lethal（2） denticleless protein homolog;CDW1;CDW1;DCAF2;DDB1 ａnd CUL4 associated fa...
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Substrate-specific adapter of a DCX （DDB1-CUL4-X-box） E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response ａnd translesion DNA synthesis. The DCX（DTL） complex, also named CRL4（CDT2） complex, mediates the polyubiquitination ａnd subsequent degradation of CDT1 ａnd CDKN1A/p21（CIP1）. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21（CIP1） degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, ａnd those containing the ＇K+4＇ motif in the PIP box, recruit the DCX（DTL） complex, leading to their degradation. In undamaged proliferating cells, the DCX（DTL） complex also promotes the ＇Lys-164＇ monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.Tissue specificity: Expressed in placenta ａnd testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus ａnd bone marrow. A low level detected in the spleen ａnd lymph node, ａnd barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.

维甲酸调节核基质相关蛋白的质量标准：

■别名：	Lethal（2） denticleless protein homolog;CDW1;CDW1;DCAF2;DDB1 ａnd CUL4 associated fa...
■交叉反应：	hu, mo
■产品类型：	一抗
■研究领域:	细胞生物细胞周期蛋白
■蛋白分子：	predicted molecular weight: 79kDa
■浓度：	1mg/1ml
■性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from hu RAMP/CDT2
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■储存液：	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
■产品应用：	WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
■保存条件：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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维甲酸调节核基质相关蛋白Anti-RAMP/CDT2的相关产品目录：





（1mg/1ml维甲酸调节核基质相关蛋白Anti-RAMP/CDT2，Lethal（2） denticleless protein homolog;CDW1;CDW1;DCAF2;DDB1 ａnd CUL4 associated fa...的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

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