组蛋白去甲基化Jarid1C抗体Anti-KDM5C/Jarid1C/SMCXSmcX protein; Xe169 protein; DXS1272E; Histone demethylase JARID1C; JmjC domain containing...
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性能参数：

中文名称：组蛋白去甲基化Jarid1C抗体
英文名称：Anti-KDM5C/Jarid1C/SMCX
别名：SmcX protein; Xe169 protein; DXS1272E; Histone demethylase JARID1C; JmjC domain containing...
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Histone demethylase that specifically demethylates ＇Lys-4＇ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ＇Lys-9＇, H3 ＇Lys-27＇, H3 ＇Lys-36＇, H3 ＇Lys-79＇ or H4 ＇Lys-20＇. Demethylates trimethylated ａnd dimethylated but not monomethylated H3 ＇Lys-4＇. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases ａnd REST at neuron-restrictive silencer elements.Tissue specificity:br>Involvement in disease:Defects in KDM5C are the cause of mental retardation syndromic X-linked JARID1C-related （MRXSJ） . MRXSJ is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior ａnd manifested during the developmental period. MRXSJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.Subcellular Location : Nucleus.Tissue Specificity : Expressed in all tissues examined. Highest levels found in brain ａnd skeletal muscle.Similarity : Belongs to the JARID1 histone demethylase family. Contains 1 ARID domain. Contains 1 JmjC domain. Contains 1 JmjN domain. Contains 2 PHD-type zinc fingers.Subunit : Part of two distinct complexes, one containing E2F6, ａnd the other containing REST.

组蛋白去甲基化Jarid1C抗体的质量标准：

■别名：	SmcX protein; Xe169 protein; DXS1272E; Histone demethylase JARID1C; JmjC domain containing...
■交叉反应：	hu, mo, rat, hrs, pig, cow, dog, Rb
■产品类型：	一抗
■研究领域:	细胞生物染色质和核信号信号转导表观遗传学
■蛋白分子：	predicted molecular weight: 176kDa
■浓度：	1mg/1ml
■性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human KDM5C
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■储存液：	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
■产品应用：	WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
■保存条件：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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组蛋白去甲基化Jarid1C抗体Anti-KDM5C/Jarid1C/SMCX的相关产品目录：





（1mg/1ml组蛋白去甲基化Jarid1C抗体Anti-KDM5C/Jarid1C/SMCX，SmcX protein; Xe169 protein; DXS1272E; Histone demethylase JARID1C; JmjC domain containing...的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

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