亨丁顿舞蹈症相互作用蛋白12抗体Anti-HIP1R/HIP12/HIP3Hip1 related; HIP12; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interactin
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性能参数：

中文名称：亨丁顿舞蹈症相互作用蛋白12抗体
英文名称：Anti-HIP1R/HIP12/HIP3
别名：Hip1 related; HIP12; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interactin
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels ａnd exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain ａnd is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region ａnd an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain ａnd shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA ａnd protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.Subcellular Location : Cytoplasm, perinuclear region. Intracytoplasmic membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments ａnd in the perinuclear region.

亨丁顿舞蹈症相互作用蛋白12抗体的质量标准：

■其它名称：	Hip1 related; HIP12; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interactin
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	细胞生物 免疫学 神经生物学
■蛋白分子：	predicted molecular weight: 119kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human HIP1R/HIP12/HIP3
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
■产品应用：	WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
■保存条件：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
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由于化学产品的特殊性，恕不接受以下投诉：
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亨丁顿舞蹈症相互作用蛋白12抗体Anti-HIP1R/HIP12/HIP3的相关产品目录：







（1mg/1ml亨丁顿舞蹈症相互作用蛋白12抗体Anti-HIP1R/HIP12/HIP3，Hip1 related; HIP12; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interactin的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

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