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肝素辅助因子II抗体,Anti-HCF2/Heparin Cofactor II,一抗 价格优惠 上海现货
点击次数:435发布时间:2012/7/19 21:40:46
更新日期:2013/5/6 10:21:49
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详细内容
肝素辅助因子II抗体Anti-HCF2/Heparin Cofactor IIHC II;HCF2;HLS2;Leuserpin 2;LS2;Protease inhibitor leuserpin 2;SERPIND1.
360TIYO.COM-上海田源公司
性能参数:
中文名称:肝素辅助因子II抗体
英文名称:Anti-HCF2/Heparin Cofactor II
别名:HC II;HCF2;HLS2;Leuserpin 2;LS2;Protease inhibitor leuserpin 2;SERPIND1.
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The herpes simplex virus (HSV) infection is initiated by VP16, a viral transcription factor that activates the viral immediate-early (IE) genes.The anticoagulant action of heparin is dependent on plasma components termed heparin cofactors. The first of these to be well characterized was antithrombin III. Heparin Cofactor II is antigenically distinct from AT III. Heparin Cofactor II is normal in patients with AT III deficiency and is low in patients with disseminated intravascular coagulation. It is expressed predominantly in liver. Its function is: thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, Heparin Cofactor II becomes the predominant thrombin inhibitor in place of antithrombin III (AT III). Also inhibits chymotrypsin, but in a glycosaminoglycan independent manner and peptides at the N terminal of Heparin Cofactor II have chemotactic activity for both monocytes and neutrophils. The N terminal acidic repeat region mediates, in part, the glycosaminoglycan accelerated thrombin inhibition. Defects in SERPIND1 are the cause of Heparin Cofactor II deficiency. Heparin Cofactor II deficiency is an important risk factor for hereditary thrombophilia, a multifactorial trait characterized by recurrent thrombosis and abnormal platelet aggregation in response to various agents. Heparin Cofactor II deficiency is inherited as an autosomal dominant disorder, in which affected individuals are prone to develop serious spontaneous thrombosis. Subcellular Location : Secreted肝素辅助因子II抗体的质量标准:
■其它名称: | HC II;HCF2;HLS2;Leuserpin 2;LS2;Protease inhibitor leuserpin 2;SERPIND1. |
■交叉反应: | hu, mo, rat |
■产品类型: | 一抗 |
■应用领域: | 心血管 细胞生物 |
■蛋白分子: | predicted molecular weight: 57kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from hu HCF2/Heparin Cofactor II |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
■产品应用: | WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200(石蜡切片需做抗原修复)not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user. |
■保存条件: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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肝素辅助因子II抗体Anti-HCF2/Heparin Cofactor II的相关产品目录:
(1mg/1ml肝素辅助因子II抗体Anti-HCF2/Heparin Cofactor II,HC II;HCF2;HLS2;Leuserpin 2;LS2;Protease inhibitor leuserpin 2;SERPIND1.的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗)
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