磷酸化活化复制因子2抗体Anti-phospho-ATF2（Ser472）CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response
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性能参数：

中文名称：磷酸化活化复制因子2抗体
英文名称：Anti-phospho-ATF2（Ser472）
别名：CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element （CRE） in the promoter of various viral ａnd cellular genes. Many of these genes are important in cell growth ａnd differentiation, ａnd in stress ａnd immune responses. ATF2 is a nuclear protein that binds DNA as a dimer ａnd can form dimers with members of the ATF/CREB ａnd Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination ａnd proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, ａnd UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase ａnd p38 MAP kinase. ATF2 is abundantly expressed in brain.Subcellular Location : Nucleus.Tissue Specificity : Abundant expression seen in the brain.Similarity : Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP domain.Contains 1 C2H2-type zinc finger.Subunit : Binds DNA as a dimer ａnd can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 ａnd SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.

磷酸化活化复制因子2抗体的质量标准：

■其它名称：	CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response
■交叉反应：	hu, mo, rat, dog, cow
■产品类型：	一抗磷酸化抗体
■应用领域:	肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 45kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human ATF2 around the phosphorylation site of Ser472
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■产品应用：	WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
■保存条件：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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2、非质量报告提及的指标投诉

磷酸化活化复制因子2抗体Anti-phospho-ATF2（Ser472）的相关产品目录：







（1mg/1ml磷酸化活化复制因子2抗体Anti-phospho-ATF2（Ser472），CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

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