磷酸化细胞信号转导分子SMAD3抗体Anti-phospho-Smad3（Ser204）SMAD3（phospho S204）; hMAD 3; hSMAD3; HSPC193; JV15 2; JV152; MAD （mothers against decapent
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性能参数：

中文名称：磷酸化细胞信号转导分子SMAD3抗体
英文名称：Anti-phospho-Smad3（Ser204）
别名：SMAD3（phospho S204）; hMAD 3; hSMAD3; HSPC193; JV15 2; JV152; MAD （mothers against decapent
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers ａnd act as anti- or Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation ａnd development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated （Smad2 ａnd 3） or BMP receptor regulated （Smad 1, 5, ａnd 8）; the common partner, （Smad4） that functions via its interaction to the various Smads; ａnd the inhibitory Smads, （Smad6 ａnd 7）. Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation ａnd translocates as a complex into the nucleus, allowing its binding to DNA ａnd transcription factors. Phosphorylation of the two TGF beta dependent serines 423 ａnd 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity ａnd TGF beta signaling.Subcellular Location : Cytoplasm. Nucleus.Similarity : Belongs to the dwarfin/SMAD family. Contains 1 MH1 （MAD homology 1） domain. Contains 1 MH2 （MAD homology 2） domain.Subunit : Monomer; in the absence of TGF-beta. Homooligomer; in the presence of TGF-beta. Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 ａnd one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex.

磷酸化细胞信号转导分子SMAD3抗体的质量标准：

■其它名称：	SMAD3（phospho S204）; hMAD 3; hSMAD3; HSPC193; JV15 2; JV152; MAD （mothers against decapent
■交叉反应：	hu, mo, rat, shp, hrs, cow, pig, Rb
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子
■蛋白分子：	predicted molecular weight: 47kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human Smad3 around the phosphorylation site of Ser204
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。

友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

磷酸化细胞信号转导分子SMAD3抗体Anti-phospho-Smad3（Ser204）的相关产品目录：







1mg/1ml 磷酸化细胞信号转导分子SMAD3抗体 Anti-phospho-Smad3（Ser204） SMAD3（phospho S204）; hMAD 3; hSMAD3; HSPC193; JV15 2; JV152; MAD （mothers against decapent的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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