脯氨酰羟化酶抗体Anti-PHD1/prolyl hydroxylaseEgl nine homolog 2; EGLN 2; EGLN2; EIT 6; EIT6; HIF P4H 1; HIF PH1; HIFPH1; HPH 3; HPH3; P
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性能参数：

中文名称：脯氨酰羟化酶抗体
英文名称：Anti-PHD1/prolyl hydroxylase
别名：Egl nine homolog 2; EGLN 2; EGLN2; EIT 6; EIT6; HIF P4H 1; HIF PH1; HIFPH1; HPH 3; HPH3; P
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor （HIF） alpha proteins ａnd hydroxylates HIF-1 alpha at Pro-402 ａnd Pro-564, ａnd HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : According to PubMed:11056053, widely expressed with highest levels in skeletal muscle ａnd heart, moderate levels in pancreas, brain （dopaminergic neurons of adult ａnd fetal substantia nigra） ａnd kidney, ａnd lower levels in lung ａnd liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney ａnd adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells ａnd coronary artery smooth muscle. According to PubMed:12788921; expressed in adult ａnd fetal heart, brain, liver, lung, skeletal muscle ａnd kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung ａnd liver ａnd fetal brain, heart spleen ａnd skeletal muscle.Similarity : Contains 1 Fe2OG dioxygenase domain.Contains 1 MYND-type zinc finger.Subunit : Monomer. Interacts with ING4; the interaction inhibits the hydroxylation of HIFs. Interacts with LIMD1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with EPAS1.

脯氨酰羟化酶抗体的质量标准：

■其它名称：	Egl nine homolog 2; EGLN 2; EGLN2; EIT 6; EIT6; HIF P4H 1; HIF PH1; HIFPH1; HPH 3; HPH3; P
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/肿瘤/心血管/免疫学/染色质和核信号
■蛋白分子：	predicted molecular weight: 44kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human PHD1/prolyl hydroxylase
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。

友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

脯氨酰羟化酶抗体Anti-PHD1/prolyl hydroxylase的相关产品目录：







1mg/1ml 脯氨酰羟化酶抗体 Anti-PHD1/prolyl hydroxylase Egl nine homolog 2; EGLN 2; EGLN2; EIT 6; EIT6; HIF P4H 1; HIF PH1; HIFPH1; HPH 3; HPH3; P的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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