产品展示
磷酸化视网膜母细胞瘤样蛋白p107抗体,Anti-phospho-p107(Thr369),一抗磷酸化抗体 价格优惠 上海现货
点击次数:155发布时间:2012/7/21 22:00:46
更新日期:2013/5/6 9:48:55
所 在 地:其它
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详细内容
磷酸化视网膜母细胞瘤样蛋白p107抗体Anti-phospho-p107(Thr369)RBL1(phospho T369); Cellular protein 107; CP107; PRB1; RBL1; Retinoblastoma like protein 1
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性能参数:
中文名称:磷酸化视网膜母细胞瘤样蛋白p107抗体
英文名称:Anti-phospho-p107(Thr369)
别名:RBL1(phospho T369); Cellular protein 107; CP107; PRB1; RBL1; Retinoblastoma like protein 1
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The pocket protein family consists of three structurally and functionally related proteins, Rb (retinoblastoma), p107, and p130. This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family. The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression. Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation . While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F. Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb. Rb, p107, and p130 each contain a conserved 'A/B pocket', which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A. There are two isoforms.Subcellular Location : Nuclear.磷酸化视网膜母细胞瘤样蛋白p107抗体的质量标准:
■其它名称: | RBL1(phospho T369); Cellular protein 107; CP107; PRB1; RBL1; Retinoblastoma like protein 1 |
■交叉反应: | hu, mo, rat, hrs, cow, dog, chk, pig, Rb |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/干细胞/细胞周期蛋白/转录调节因子 |
■蛋白分子: | predicted molecular weight: 121kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthesised phosphopeptide derived from human p107 around the phosphorylation site of Thr369 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化视网膜母细胞瘤样蛋白p107抗体Anti-phospho-p107(Thr369)的相关产品目录:
1mg/1ml 磷酸化视网膜母细胞瘤样蛋白p107抗体 Anti-phospho-p107(Thr369) RBL1(phospho T369); Cellular protein 107; CP107; PRB1; RBL1; Retinoblastoma like protein 1的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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