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磷酸化B-Raf抗体,Anti-phospho-B-Raf (Ser446),一抗 价格优惠 上海现货
点击次数:108发布时间:2012/7/23 0:29:47
更新日期:2013/5/6 9:32:11
所 在 地:其它
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详细内容
磷酸化B-Raf抗体Anti-phospho-B-Raf (Ser446)94 kDa B raf protein; B raf 1; B Raf proto oncogene serine threonine protein kinase; BRAF
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化B-Raf抗体
英文名称:Anti-phospho-B-Raf (Ser446)
别名:94 kDa B raf protein; B raf 1; B Raf proto oncogene serine threonine protein kinase; BRAF
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The Raf kinases are important intermediates in signal transduction. Raf protein family members, including A Raf and B Raf, have intrinsic serine/threonine kinase activity. Interaction between Ras proteins and Raf proteins results in Raf-mediated phosphorylation and activation of MEK (also known as MAP kinase kinase). Defects in BRAF are involved in a wide range of cancers. B-Raf is a serine/threonine protein kinase that acts as a signal transducer from membrane-associated receptors to nuclear transcription factors. 1 BRAF is important for the regulation of cell proliferation and determination of cell fate during embryogenesis. BRAF acts downstream of Ras and upstream of MEK in the Ras-Raf-MEK-ERK signal transduction pathway, which is a conserved RAS-activated protein kinase cascade that regulates cell growth, proliferation, and differentiation in response to growth factors, cytokines, and hormones.BRAF蛋白是有丝分裂原活化的蛋白激酶/细胞外信号调节激酶途径蛋白。正常的B-Raf蛋白的功能是传递来自细胞膜的信号,在Ras-Raf-MEK-ERK信号转导调节途径中有着重要的作用。BRAF是一种在癌细胞的生长和存活中起到关键作用的蛋白质,并且在大多数恶性黑素瘤患者和少数结肠癌、乳腺癌和肺癌患者中发生突变,目前BRAF也用于恶性黑素瘤和肿瘤的研究。磷酸化B-Raf抗体的质量标准:
■其它名称: | 94 kDa B raf protein; B raf 1; B Raf proto oncogene serine threonine protein kinase; BRAF |
■交叉反应: | hu |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 94kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human B-Raf around the phosphorylation site of Ser446 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化B-Raf抗体Anti-phospho-B-Raf (Ser446)的相关产品目录:
1mg/1ml 磷酸化B-Raf抗体 Anti-phospho-B-Raf (Ser446) 94 kDa B raf protein; B raf 1; B Raf proto oncogene serine threonine protein kinase; BRAF 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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