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α-连环蛋白抗体(钙粘蛋白相关蛋白),Anti-Alpha-Catenin/CTNNA1,一抗 价格优惠 上海现货
点击次数:155发布时间:2012/7/23 11:41:08
更新日期:2013/4/11 11:01:22
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详细内容
α-连环蛋白抗体(钙粘蛋白相关蛋白)Anti-Alpha-Catenin/CTNNA1alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadher
360TIYO.COM-上海田源公司
性能参数:
中文名称:α-连环蛋白抗体(钙粘蛋白相关蛋白)
英文名称:Anti-Alpha-Catenin/CTNNA1
别名:alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadher
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.细胞粘附蛋白(Call Adhesion Protein)α-catenin是一种多功能的蛋白质,能链接E-\\N-\\P-钙粘附分子,具有参与细胞粘附和介导信号转导的双重功能,并与肿瘤的发生发展及浸润密切相关。在正常个体中,βα-catenin和钙黏蛋白形成复合体,介导同型细胞的粘附,维持细胞的稳定;同时,α-catenin作为Wnt/α-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。在恶性肿瘤中,α连环蛋白的表达呈现明显的异质性,促使细胞异常增殖,还可使细胞之间的黏附性减弱,侵袭性增强。α-连环蛋白抗体(钙粘蛋白相关蛋白)的质量标准:
■其它名称: | alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadher |
■交叉反应: | hu, mo, rat, pig, hrs, Rb, dog, chk |
■产品类型: | 一抗 |
■应用领域: | /心血管/神经生物学/信号转导/干细胞/细胞粘附分子/细胞骨架 |
■蛋白分子: | predicted molecular weight: 102kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Catenin C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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α-连环蛋白抗体(钙粘蛋白相关蛋白)Anti-Alpha-Catenin/CTNNA1的相关产品目录:
1mg/1ml α-连环蛋白抗体(钙粘蛋白相关蛋白) Anti-Alpha-Catenin/CTNNA1 alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadher的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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