磷酸化半胱氨酸蛋白酶9抗体Anti-Phospho-Caspase-9 （Thr125）APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor
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性能参数：

中文名称：磷酸化半胱氨酸蛋白酶9抗体
英文名称：Anti-Phospho-Caspase-9 （Thr125）
别名：APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Caspase 9 （also known as ICE like apoptotic protease 6 （ICE LAP6）, apoptotic protease Mch6, ａnd apoptotic protease activating factor 3 （Apaf3）） is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer ａnd has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution ａnd cleaves/activates Caspase 3 ａnd Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, BclXL, cIAP1, cIAP2, XIAP, ａnd Livin. This caspase becomes activated when recruited to Apaf1/cytochrome c complex, ａnd following cleavage by Apaf1, granzyme B, Caspase 3, possibly Caspase 8 ａnd Caspase 10 into large p37 ａnd small p10 subunits. Caspase 9 intereacts with BIRC7 ａnd has been shown to cleave PARP ａnd vimentin. Tissue Specificity : Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, ａnd pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.Similarity : Belongs to the peptidase C14A family. Contains 1 CARD domain.Subunit : Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa （p35） ａnd a 10 kDa （p10） subunit. Caspase-9 ａnd APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C ａnd ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 ａnd BIRC7. Interacts （inactive form） with EFHD2. Interacts with HAX1.Caspase-9半胱氨酸蛋白酶家族成员，又称ICE-Lap6（ICE Like apoptotease 6）参与细胞凋亡过程和细胞因子的加工过程，在许多胚胎和成人组织中都有分布。此抗体主要用于肿瘤凋亡的研究。

磷酸化半胱氨酸蛋白酶9抗体的质量标准：

■其它名称：	APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor
■交叉反应：	hu, rat, mo
■产品类型：	一抗磷酸化抗体
■应用领域:	/细胞凋亡
■蛋白分子：	predicted molecular weight: 52kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human Caspase-9 around the phosphorylation site of Thr125
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化半胱氨酸蛋白酶9抗体Anti-Phospho-Caspase-9 （Thr125）的相关产品目录：







1mg/1ml 磷酸化半胱氨酸蛋白酶9抗体 Anti-Phospho-Caspase-9 （Thr125） APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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