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磷酸化β 连环素蛋白抗体Anti-Phospho-Beta-Catenin (Ser552)CTNNB1; CHBCAT; CTNNB1; CTNNB; Beta-catenin; Catenin beta-1; PRO2286; FLJ37923; FLJ25606;
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中文名称:磷酸化β 连环素蛋白抗体
英文名称:Anti-Phospho-Beta-Catenin (Ser552)
别名:CTNNB1; CHBCAT; CTNNB1; CTNNB; Beta-catenin; Catenin beta-1; PRO2286; FLJ37923; FLJ25606;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Tissue Specificity : Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon.Similarity : Belongs to the beta-catenin family.Contains 12 ARM repeats.细胞粘附蛋白(Call Adhesion Protein) β连环素蛋白β-catenin是一种多功能的蛋白质,能链接E-\\N-,钙粘附分子具有参与细胞粘附和介导信号转导的双重功能,并与肿瘤的发生发展及浸润密切相关。 在正常个体中,β-catenin和钙黏蛋白形成复合体,介导同型细胞的粘附,维持细胞的稳定;同时,β-catenin作为Wnt/β-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。 在恶性肿瘤中,β-catenin的表达呈现明显的异质性,促使细胞异常增殖,还可使细胞之间的黏附性减弱,侵袭性增强。磷酸化β 连环素蛋白抗体的质量标准:
■其它名称: | CTNNB1; CHBCAT; CTNNB1; CTNNB; Beta-catenin; Catenin beta-1; PRO2286; FLJ37923; FLJ25606; |
■交叉反应: | hu, mo, rat, Rb, pig, chk |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/信号转导/细胞凋亡/细胞粘附分子/细胞分化 |
■蛋白分子: | predicted molecular weight: 92kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human Beta-Catenin around the phosphorylation site of Ser552 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化β 连环素蛋白抗体Anti-Phospho-Beta-Catenin (Ser552)的相关产品目录:
1mg/1ml 磷酸化β 连环素蛋白抗体 Anti-Phospho-Beta-Catenin (Ser552) CTNNB1; CHBCAT; CTNNB1; CTNNB; Beta-catenin; Catenin beta-1; PRO2286; FLJ37923; FLJ25606; 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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