细胞毒性受体NK-p30抗体Anti-CD337/NKp30/NCR3Natural killer cell p30-related protein; natural cytotoxicity triggering receptor 3; 1C7;
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性能参数：

中文名称：细胞毒性受体NK-p30抗体
英文名称：Anti-CD337/NKp30/NCR3
别名：Natural killer cell p30-related protein; natural cytotoxicity triggering receptor 3; 1C7;
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：NCR3 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer （NK） cells to mediate tumor cell lysis. It is a member of the Ig superfamily ａnd may cooperate with NKp46 ａnd NKp44 in the induction of cytotoxicity against a variety of target cells ａnd is selectively expressed by all NK cells, both freshly isolated ａnd cultured in IL2, thus representing an optimal marker for NK cell identification. Similar to NKp46 ａnd CD16, NKp30 associated with CD3 zeta chains becomes tyrosine phosphorylated following cell treatment with pervanadate. Its extracelluar portion is characterized by a single domain of the V-type ａnd by a region rich in hydrophobic amino acids, potentially involved in protein/protein interactions that connects the Ig V-like domain with the transmembrane portion. It is selectively expressed by all resting ａnd activated NK cells ａnd weakly expressed in spleen.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Selectively expressed by all resting ａnd activated NK cells ａnd weakly expressed in spleen.Similarity : Belongs to the natural cytotoxicity receptor （NCR） family. Contains 1 Ig-like （immunoglobulin-like） domain.Subunit : Homodimer in the unliganted form. Interacts with CD3Z. Interacts with ａnd is activated by binding to B7H6. Interacts with ａnd is activated by binding to BAG6.细胞毒性受体家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表达于所有静止和活化的NK细胞，而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合（交联）引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素，而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。

细胞毒性受体NK-p30抗体的质量标准：

■其它名称：	Natural killer cell p30-related protein; natural cytotoxicity triggering receptor 3; 1C7;
■交叉反应：	hu, rat
■产品类型：	一抗
■应用领域:	/免疫学/干细胞/细胞表面分子/自然杀伤细胞/淋巴细胞
■蛋白分子：	predicted molecular weight: 22kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human CD337
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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细胞毒性受体NK-p30抗体Anti-CD337/NKp30/NCR3的相关产品目录：







1mg/1ml 细胞毒性受体NK-p30抗体 Anti-CD337/NKp30/NCR3 Natural killer cell p30-related protein; natural cytotoxicity triggering receptor 3; 1C7; 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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