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转铁蛋白受体抗体,Anti-Transferrin receptor,一抗 价格优惠 上海现货
点击次数:289发布时间:2012/7/23 22:12:04
更新日期:2013/4/11 10:58:27
所 在 地:其它
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详细内容
转铁蛋白受体抗体Anti-Transferrin receptorCD 71; CD71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TFRC; TR; Transferrin receptor (p90
360TIYO.COM-上海田源公司
性能参数:
中文名称:转铁蛋白受体抗体
英文名称:Anti-Transferrin receptor
别名:CD 71; CD71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TFRC; TR; Transferrin receptor (p90
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro.Subcellular Location : Cell membraneSimilarity : Belongs to the peptidase M28 family. M28B subfamily.Subunit : Homodimer; disulfide-linked. Binds one transferrin molecule per subunit.Interacts with SH3BP4.转铁蛋白及转铁蛋白受体(TfnrR)是机体铁代谢中的重要因子,铁是细胞生长增殖、代谢的必需元素,转铁蛋白受体(TfR)介导的胞吞作用是细胞摄取铁的主要途径。肿瘤细胞因增殖生长旺盛,对铁的需求高,所以肿瘤细胞有比正常细胞更多的转铁蛋白受体的表达。转铁蛋白受体抗体的质量标准:
■其它名称: | CD 71; CD71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TFRC; TR; Transferrin receptor (p90 |
■交叉反应: | hu, mo, rat, pig, cow, hrs, dog, chk |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/心血管/细胞生物/免疫学/神经生物学/干细胞/糖尿病/细胞表面分子/细胞类型标志物/淋巴细胞/t-淋巴细胞/b-淋巴细胞 |
■蛋白分子: | predicted molecular weight: 74/85kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human CD71 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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转铁蛋白受体抗体Anti-Transferrin receptor的相关产品目录:
1mg/1ml 转铁蛋白受体抗体 Anti-Transferrin receptor CD 71; CD71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TFRC; TR; Transferrin receptor (p90 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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