信号调节蛋白α抗体Anti-CD172a/SIRP AlphaSignal regulatory protein alpha type 1; BIT; Brain Ig like molecule with tyrosine based ac
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性能参数：

中文名称：信号调节蛋白α抗体
英文名称：Anti-CD172a/SIRP Alpha
别名：Signal regulatory protein alpha type 1; BIT; Brain Ig like molecule with tyrosine based ac
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Protein tyrosine phosphatases （PTPases） SHP1 ａnd SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases ａnd cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse ａnd cattle by several labs ａnd was designated SIRPa （1）,SHPS1 , MyD1, BIT ａnd p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR ａnd src, ａnd a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones ａnd cell adhesion ａnd plays a general role in different physiological ａnd pathological processes.Subcellular Location : Membrane; Single-pass type I membraneprotein.Tissue Specificity : Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle ａnd pancreas.Similarity : Contains 2 Ig-like C1-type （immunoglobulin-like） domains. Contains 1 Ig-like V-type （immunoglobulin-like） domain.Subunit : Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR （By similarity）. Binds JAK2 irrespective of its phosphorylation status ａnd forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

信号调节蛋白α抗体的质量标准：

■其它名称：	Signal regulatory protein alpha type 1; BIT; Brain Ig like molecule with tyrosine based ac
■交叉反应：	hu, mo, rat, dog, cow, hrs, pig, hrs
■产品类型：	一抗
■应用领域:	/神经生物学
■蛋白分子：	predicted molecular weight: 56kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human CD172a C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
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由于化学产品的特殊性，恕不接受以下投诉：
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信号调节蛋白α抗体Anti-CD172a/SIRP Alpha的相关产品目录：







1mg/1ml 信号调节蛋白α抗体 Anti-CD172a/SIRP Alpha Signal regulatory protein alpha type 1; BIT; Brain Ig like molecule with tyrosine based ac的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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