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细胞毒性受体NK-p46抗体,Anti-CD335/NKp46/NCR1,一抗 价格优惠 上海现货
点击次数:182发布时间:2012/7/23 22:12:59
更新日期:2013/4/11 10:58:06
所 在 地:其它
产品型号:
优质供应
详细内容
细胞毒性受体NK-p46抗体Anti-CD335/NKp46/NCR1Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p4
360TIYO.COM-上海田源公司
性能参数:
中文名称:细胞毒性受体NK-p46抗体
英文名称:Anti-CD335/NKp46/NCR1
别名:Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p4
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Selectively expressed by both resting and activated NK cells.Similarity : Belongs to the natural cytotoxicity receptor (NCR) family.Contains 2 Ig-like (immunoglobulin-like) domains.Subunit : Interacts with CD247 and FCER1G.NKp46是很重要的的自然细胞毒受体,在自然杀伤作用中起关键作用。细胞毒性受体家族(NCRs)主要有:NKp46、NKp44和NKp30,其中NKp46和NKp30表达于所有静止和活化的NK细胞,而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合(交联)引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素,而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。细胞毒性受体NK-p46抗体的质量标准:
■其它名称: | Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p4 |
■交叉反应: | hu, mo, rat, dog, cow, hrs, shp, pig |
■产品类型: | 一抗 |
■应用领域: | /肿瘤 |
■蛋白分子: | predicted molecular weight: 33/36kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human CD335 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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细胞毒性受体NK-p46抗体Anti-CD335/NKp46/NCR1的相关产品目录:
1mg/1ml 细胞毒性受体NK-p46抗体 Anti-CD335/NKp46/NCR1 Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p4的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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