白介素2受体γ链抗体Anti-IL-2R gamma/CD132IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; common cytokine receptor gamma c
360TIYO.COM-上海田源公司

性能参数：

中文名称：白介素2受体γ链抗体
英文名称：Anti-IL-2R gamma/CD132
别名：IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; common cytokine receptor gamma c
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Interleukin 2 （IL2） receptor gamma chain （IL5212R gamma） is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, ａnd neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, ａnd gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 （IL2R alpha）, CD122 （IL2R beta）, CD124 （IL4R alpha）, CD127 （IL7R）, ａnd others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, ａnd IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development ａnd activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 （Janus Kinase 3）, JAK1, Syc, ａnd Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 （Signal Transducer ａnd Activator of Transcription 3）, STAT5, ａnd STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, ａnd IL9 exert their effects through cascades, which activate STAT3 ａnd STAT5, while IL4 activates STAT6. IL2 ａnd IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency （X SCID）, a disease that is characterized by the absence of T cells ａnd NK cells.Subcellular Location : Membrane; Single-pass type I membrane protein.Similarity : Contains 1 fibronectin type-III domain.Subunit : The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 ａnd probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.

白介素2受体γ链抗体的质量标准：

■其它名称：	IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; common cytokine receptor gamma c
■交叉反应：	hu, mo, rat, pig, dog, cow
■产品类型：	一抗
■应用领域:	/细胞生物/免疫学/信号转导/细胞膜受体
■蛋白分子：	predicted molecular weight: 41kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human IL-2R gamma C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

白介素2受体γ链抗体Anti-IL-2R gamma/CD132的相关产品目录：







1mg/1ml 白介素2受体γ链抗体 Anti-IL-2R gamma/CD132 IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; common cytokine receptor gamma c的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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