磷酸化周期素依赖激酶2抗体Anti-Phospho-cdc2 （Tyr15）CDC2（Phospho-Tyr15）; P34CDC2; Cdc 2; CDK 1; CDK1; Cell division control protein 2; Cell di
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性能参数：

中文名称：磷酸化周期素依赖激酶2抗体
英文名称：Anti-Phospho-cdc2 （Tyr15）
别名：CDC2（Phospho-Tyr15）; P34CDC2; Cdc 2; CDK 1; CDK1; Cell division control protein 2; Cell di
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The cell division control protein cdc2, also known as cyclin dependent kinase 1 （Cdk1） or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase ａnd mitosis. Cdc2 exists as a complex with both cyclin A ａnd cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding ａnd phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 ａnd Tyr14. Phosphorylation at Tyr15 ａnd inhibition of Cdc2 is carried out by WEE1 ａnd MIK protein kinases while Tyr15 dephosphorylation ａnd activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development ａnd degeneration. Cdc2蛋白激酶也被称作细胞周期蛋白依赖性激酶1 （cyclin-dependent kinase 1, CDK1）或M期促进因子（M-phase promoting factor, MPF），是细胞周期蛋白依赖性激酶家族成员，参与真核细胞周期的调控。Cdc2-cyclin B活化后可启动有丝分裂，其活化受到严格调控。Cdc2-cyclin B是丝氨酸/苏氨酸蛋白酶，由催化亚基Cdc2和正向调节亚基cyclin B （B1 异构体） 组成。Cdc2与细胞周期蛋白B的结合对激酶的激活是非常重要的。在G2期，Cdc2-cyclin B处于非活化状态，这是因为其两个负向调控位点T14和T15分别被抑制蛋白激酶Myt1和Wee1磷酸化。在G2后期，T14和T15两个位点在Cdc25C蛋白磷酸酶作用下去磷酸化，使Cdc2-cyclin B复合体活化，从而引发有丝分裂的启始。

磷酸化周期素依赖激酶2抗体的质量标准：

■其它名称：	CDC2（Phospho-Tyr15）; P34CDC2; Cdc 2; CDK 1; CDK1; Cell division control protein 2; Cell di
■交叉反应：	hu, rat, mo
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/细胞生物/免疫学/细胞周期蛋白/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 34kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human cdc2 around the phosphorylation site of Tyr15
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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磷酸化周期素依赖激酶2抗体Anti-Phospho-cdc2 （Tyr15）的相关产品目录：







1mg/1ml 磷酸化周期素依赖激酶2抗体 Anti-Phospho-cdc2 （Tyr15） CDC2（Phospho-Tyr15）; P34CDC2; Cdc 2; CDK 1; CDK1; Cell division control protein 2; Cell di的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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