原癌基因蛋白/活化蛋白1抗体Anti-C-jun/AP-1Jun oncogene; JUN; Activator Protein 1; AP 1; AP1; AP-1; Enhancer Binding Protein AP1; Jun
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性能参数：

中文名称：原癌基因蛋白/活化蛋白1抗体
英文名称：Anti-C-jun/AP-1
别名：Jun oncogene; JUN; Activator Protein 1; AP 1; AP1; AP-1; Enhancer Binding Protein AP1; Jun
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, ａnd it encodes a protein which is highly homologous to the viral protein. cJun （previously known as the Fos binding protein p39） ａnd c Fos form a complex in the nucleus. AP 1 （activating protein 1） is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression ａnd function of cell cycle regulators such as Cyclin D1, p53, p21 （cip1/waf1）, p19 （ARF） ａnd p16. Fos ａnd Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations ａnd deletions in human malignancies.Subcellular Location : Nucleus.Similarity : Belongs to the bZIP family. Jun subfamily.Contains 1 bZIP domain.Subunit : Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA （By similarity）. Interacts with HIVEP3 ａnd MYBBP1A （By similarity）. Interacts with SP1, SPIB ａnd TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts （via its basic DNA binding ａnd leucine zipper domains） with SMAD3 （via an N-terminal domain）; the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.转录调节因子（Transcriptin Regulators） C-jun（Oncoprotein C-jun：active protein 1）基因与鸟类肉瘤病毒17的转化基因具有同源性，是早期应答基因家族成员。主要用于各种恶性肿瘤的研究。C-jun又称应激活化蛋白激酶.

原癌基因蛋白/活化蛋白1抗体的质量标准：

■其它名称：	Jun oncogene; JUN; Activator Protein 1; AP 1; AP1; AP-1; Enhancer Binding Protein AP1; Jun
■交叉反应：	hu, rat, mo, cow, shp, dog, chk, pig
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/信号转导/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 36kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human C-jun C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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原癌基因蛋白/活化蛋白1抗体Anti-C-jun/AP-1的相关产品目录：







1mg/1ml 原癌基因蛋白/活化蛋白1抗体 Anti-C-jun/AP-1 Jun oncogene; JUN; Activator Protein 1; AP 1; AP1; AP-1; Enhancer Binding Protein AP1; Jun的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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