细胞周期调控因子34Anti-CDC34/UBC3Cell division cycle 34; Cell division cycle 34 homolog; E2 CDC34; UBC 3; UBC3; UBE2 R1;
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性能参数：

中文名称：细胞周期调控因子34
英文名称：Anti-CDC34/UBC3
别名：Cell division cycle 34; Cell division cycle 34 homolog; E2 CDC34; UBC 3; UBC3; UBE2 R1;
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The Cdc 34 gene represents a mammalian homolog of the group of yeast Cdc 34 genes required for the late G1 - S phase transition. A key negative regulator of mitosis, the protein kinase Wee 1, is degraded in a Cdc 34 dependent fashion in Xenopus egg extracts. This proteolysis event is required for a timely entrance into mitosis ａnd is inhibited when DNA replication is blocked. Therefore, the DNA replication checkpoint can prevent mitosis by suppressing the proteolysis of Wee 1 during S phase. The human Cdc 34 gene is located on the far telomeric region of 19p13. Mutants in the gene Cdc 34 of the yeast Saccharomyces cerevisiae are defective in the transition from G1 to the S phase of the cell cycle. This gene was cloned ａnd shown to encode a 295 residue protein that has substantial sequence similarity to yeast Rad6 protein required for a variety of cellular functions including DNA repair ａnd was recently shown to encode a ubiquitin conjugating enzyme. When produced in Escherichia coli, the Cdc 34 gene product catalyzes the covalent attachment of ubiquitin to histones H2A ａnd H2B in vitro, demonstrating that the Cdc 34 protein is another distinct member of the family of ubiquitin conjugating enzymes. The cell cycle function of Cdc 34 is thus likely to be mediated by the ubiquitin conjugating activity of its product.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription.Similarity : Belongs to the ubiquitin-conjugating enzyme family.经研究证实细胞周期调控因子Cdc34是泛素转运酶E2中的成员,参与G1期周期素的降解,在进化上高度保守。

细胞周期调控因子34的质量标准：

■其它名称：	Cell division cycle 34; Cell division cycle 34 homolog; E2 CDC34; UBC 3; UBC3; UBE2 R1;
■交叉反应：	hu, mo, rat, Gpig, cow, chk, dog
■产品类型：	一抗
■应用领域:	/细胞生物/细胞凋亡/细胞周期蛋白/转录调节因子
■蛋白分子：	predicted molecular weight: 26kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human Cdc34 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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细胞周期调控因子34Anti-CDC34/UBC3的相关产品目录：







1mg/1ml 细胞周期调控因子34 Anti-CDC34/UBC3 Cell division cycle 34; Cell division cycle 34 homolog; E2 CDC34; UBC 3; UBC3; UBE2 R1; 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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