磷酸化细胞周期检测点激酶1抗体Anti-phospho-CHEK1 （Ser345）Cell cycle checkpoint kinase; Checkpoint , S. pombe, homolog of, 1; Checkpoint kinase 1; C
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性能参数：

中文名称：磷酸化细胞周期检测点激酶1抗体
英文名称：Anti-phospho-CHEK1 （Ser345）
别名：Cell cycle checkpoint kinase; Checkpoint , S. pombe, homolog of, 1; Checkpoint kinase 1; C
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic dependent kinase Cdc2, which regulates entry into mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of Cdc2. It is hypothesized that Chk1 induces serine 216 phosphorylation of Cdc25C ａnd subsequent 14-3-3 binding negatively regulated Cdc25C, thus preventing it from activating Cdc2.Subcellular Location : Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B.Tissue Specificity : Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine ａnd colon.Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. Contains 1 protein kinase domain.Subunit : Interacts （phosphorylated by ATR） with RAD51. Interacts with ａnd phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1. Interacts with BRCA1. Interacts with ａnd phosphorylates CDC25A, CDC25B ａnd CDC25C. Interacts with FBXO6, which regulates CHEK1. Interacts with PPM1D, which regulates CHEK1 through dephosphorylation. Interacts with TIMELESS; DNA damage-dependent. Interacts with FEM1B; activates CHEK1 in response to stress. Interacts with TLK1. Interacts with XPO1 ａnd YWHAZ.Chk1作为Cdks的调节参与细胞周期调节过程,是生物进化过程中非常保守的蛋白激酶，在DNA损伤引起的细胞周期检测点调节中有着非常重要的作用.在细胞周期检测点信号传导通路中，Chkl和Chk2起着重要作用，主要参与G2/M期细胞周期检测点信号传导.

磷酸化细胞周期检测点激酶1抗体的质量标准：

■其它名称：	Cell cycle checkpoint kinase; Checkpoint , S. pombe, homolog of, 1; Checkpoint kinase 1; C
■交叉反应：	hu, mo, rat, Rb, hrs, cow, dog, chk
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 52kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human CHEK1 around the phosphorylation site of Ser345
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化细胞周期检测点激酶1抗体Anti-phospho-CHEK1 （Ser345）的相关产品目录：







1mg/1ml 磷酸化细胞周期检测点激酶1抗体 Anti-phospho-CHEK1 （Ser345） Cell cycle checkpoint kinase; Checkpoint , S. pombe, homolog of, 1; Checkpoint kinase 1; C的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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