细胞角蛋白10抗体Anti-CK1056 kDa cytokeratin; CK 10; ck10; Cytokeratin 10; Cytokeratin 6B; Cytokeratin VIB; Cytokera
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性能参数：

中文名称：细胞角蛋白10抗体
英文名称：Anti-CK10
别名：56 kDa cytokeratin; CK 10; ck10; Cytokeratin 10; Cytokeratin 6B; Cytokeratin VIB; Cytokera
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Cytokeratin 10 is a heterotetramer of two type I ａnd two type II keratins. Cytokeratin 10 is generally associated with keratin 1. It is seen in all suprabasal cell layers including stratum corneum. A number of alleles are known that mainly differ in the Gly-rich region （positions 490-560）. Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis （EHK）, also known as bullous congenital ichthyosiform erythroderma （BCIE） or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering ａnd a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters ａnd superficial erosions due to cytolysis. Within a few weeks, the erythroderma ａnd blister formation diminish ａnd hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis （AEI）, also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical ａnd histologic features of both epidermolytic hyperkeratosis ａnd ichthyosis bullosa of Siemens.细胞角蛋白是形成上皮细胞细胞骨架中间纤维的一类结构相关蛋白。CK10属于I型角蛋白，常常与CK1一起存在。缺失CK10与表皮松解性角化症（EHK）以及表皮松解性鳞癣病（AEI）密切相关。主要标记上皮的基底上层和颗粒细胞层细胞，同时CK10表达与细胞的分化程度呈正比，高分化者常阳性更强，故常用于鳞状细胞癌的诊断。

细胞角蛋白10抗体的质量标准：

■其它名称：	56 kDa cytokeratin; CK 10; ck10; Cytokeratin 10; Cytokeratin 6B; Cytokeratin VIB; Cytokera
■交叉反应：	hu, mo, rat, hrs, cow, dog, Rb, pig, Gpig
■产品类型：	一抗
■应用领域:	/肿瘤/细胞周期蛋白
■蛋白分子：	predicted molecular weight: 56kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human CK10
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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细胞角蛋白10抗体Anti-CK10的相关产品目录：







1mg/1ml 细胞角蛋白10抗体 Anti-CK10 56 kDa cytokeratin; CK 10; ck10; Cytokeratin 10; Cytokeratin 6B; Cytokeratin VIB; Cytokera的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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