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酪蛋白激酶2相互作用蛋白1抗体,Anti-CKIP-1,一抗 价格优惠 上海现货
点击次数:185发布时间:2012/7/26 15:20:15
更新日期:2013/5/3 15:45:03
所 在 地:其它
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详细内容
酪蛋白激酶2相互作用蛋白1抗体Anti-CKIP-1PLEKHO1; C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting pro
360TIYO.COM-上海田源公司
性能参数:
中文名称:酪蛋白激酶2相互作用蛋白1抗体
英文名称:Anti-CKIP-1
别名:PLEKHO1; C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting pro
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2(CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. [SUBUNIT] Heterodimer or homodimer. [SUBCELLULAR LOCATION] Cell membrane. Nucleus. Cytoplasm. [TISSUE SPECIFICITY] Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cancer cell lines such as MOLT-4, HEK293 and Jurkat cells.酪蛋白激酶2相互作用蛋白1是近年来发现的一种重要分子,它通过与其他分子的相互作用在许多细胞行为中都发挥着重要的作用。 CKIP-1还具有促进细胞凋亡的作用。CKIP-1可以与caspase-3形成正反馈环,增强肿瘤细胞的凋亡。酪蛋白激酶2相互作用蛋白1抗体的质量标准:
■其它名称: | PLEKHO1; C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting pro |
■交叉反应: | hu, rat, mo |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/细胞凋亡 |
■蛋白分子: | predicted molecular weight: 45kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human CKIP-1 C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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酪蛋白激酶2相互作用蛋白1抗体Anti-CKIP-1的相关产品目录:
1mg/1ml 酪蛋白激酶2相互作用蛋白1抗体 Anti-CKIP-1 PLEKHO1; C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting pro的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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