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磷酸化cyclin D1抗体Anti-Phospho-Cyclin D1 (Thr286)AI327039; B cell ccl/lymphoma 1; B cell leukemia 1; B-cell CLL/lymphoma 1; B-cell leukemia
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性能参数:
中文名称:磷酸化cyclin D1抗体
英文名称:Anti-Phospho-Cyclin D1 (Thr286)
别名:AI327039; B cell ccl/lymphoma 1; B cell leukemia 1; B-cell CLL/lymphoma 1; B-cell leukemia
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.细胞周期素D1蛋白(Cyclin D1)是细胞周期中的重要调控因子,它作用于细胞周期的G1→S期调控点,为G1期的限速步骤。细胞周期蛋白D1-Cyclin D1的过度表达使细胞周期G1期缩短,细胞生长对有丝分裂原和粘附信号的需求降低,*终引发肿瘤的发生。该抗原的氨基酸序列抗原决定簇-结合位点,我们选在了细胞质的粗面内质网。越来越多的研究表明。CyclinD1在正常细胞周期及肿瘤的调节中起着重要作用。磷酸化cyclin D1抗体的质量标准:
■其它名称: | AI327039; B cell ccl/lymphoma 1; B cell leukemia 1; B-cell CLL/lymphoma 1; B-cell leukemia |
■交叉反应: | hu, rat, mo |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤 |
■蛋白分子: | predicted molecular weight: 32kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human Cyclin D1 around the phosphorylation site of Thr286 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化cyclin D1抗体Anti-Phospho-Cyclin D1 (Thr286)的相关产品目录:
1mg/1ml 磷酸化cyclin D1抗体 Anti-Phospho-Cyclin D1 (Thr286) AI327039; B cell ccl/lymphoma 1; B cell leukemia 1; B-cell CLL/lymphoma 1; B-cell leukemia的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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