磷酸化周期素B1抗体Anti-Phospho-Cyclin B1（Ser133）CCNB 1; CCNB; CCNB1; G2 mitotic specific cyclin B1.
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性能参数：

中文名称：磷酸化周期素B1抗体
英文名称：Anti-Phospho-Cyclin B1（Ser133）
别名：CCNB 1; CCNB; CCNB1; G2 mitotic specific cyclin B1.
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：In mammals, cyclin B associates with inactive p34 cdc2 which facilitates phosphorylation of p34 cdc2 at amino acids 14 Thr ａnd 15 Tyr. This maintains the inactive state until the end of G2 phase. The inactive cyclin B p34 cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates amino acids 14Thr ａnd 15Tyr of p34 cdc2, rendering the complex active at the G2 / M boundary. This mitotic kinase complex remains active until the metaphase / anaphase transition when cyclin B is degraded. This degradation process is ubiquitin dependent ａnd is necessary for the cell to exit mitosis. Therefore, cyclin B p34 cdc2 plays a critical role in G2 to M transition. Two alternative transcripts have been found, a constitutively expressed transcript, ａnd a cell cycle-regulated transcript that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.Subcellular Location : Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.Similarity : Belongs to the cyclin family. Cyclin AB subfamily.Subunit : Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor （MPF）. The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 ａnd CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization.主要出现在G2期。Cyclin B是细胞周期调节必不可少的条件。 细胞周期素B1是细胞周期调节因子，它的异常表达将导致细胞周期发生紊乱，致使肿瘤形成.

磷酸化周期素B1抗体的质量标准：

■其它名称：	CCNB 1; CCNB; CCNB1; G2 mitotic specific cyclin B1.
■交叉反应：	hu, mo, rat, pig
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤
■蛋白分子：	predicted molecular weight: 48kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human Cyclin B1 around the phosphorylation site of Ser133
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化周期素B1抗体Anti-Phospho-Cyclin B1（Ser133）的相关产品目录：







1mg/1ml 磷酸化周期素B1抗体 Anti-Phospho-Cyclin B1（Ser133） CCNB 1; CCNB; CCNB1; G2 mitotic specific cyclin B1. 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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