磷酸化D酪氨酸激酶衰减蛋白2抗体Anti-Phospho-p56Dok2（Tyr299）Docking protein 2 56kDa; Docking protein 2 antibody DOK 2; DOK R; Downstream of tyrosine k
360TIYO.COM-上海田源公司

性能参数：

中文名称：磷酸化D酪氨酸激酶衰减蛋白2抗体
英文名称：Anti-Phospho-p56Dok2（Tyr299）
别名：Docking protein 2 56kDa; Docking protein 2 antibody DOK 2; DOK R; Downstream of tyrosine k
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Docking proteins interact with receptor tyrosine kinases ａnd mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction ａnd cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells ａnd tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 ａnd DOK2 proteins ａnd their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras ａnd that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia （CML）, which is characterized by a Philadelphia chromosome translocation t（9;22）. Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.Tissue Specificity : Highly expressed in spleen ａnd lung.Similarity : Belongs to the DOK family. Type A subfamily.Contains 1 IRS-type PTB domain.Contains 1 PH domain.Subunit : Interacts with phosphorylated RASGAP ａnd EGFR. Interacts with RET ａnd NCK. Interacts （via PH domain） with TEK/TIE2 （tyrosine phosphorylated）.

磷酸化D酪氨酸激酶衰减蛋白2抗体的质量标准：

■其它名称：	Docking protein 2 56kDa; Docking protein 2 antibody DOK 2; DOK R; Downstream of tyrosine k
■交叉反应：	hu, pig, dog, hrs
■产品类型：	一抗磷酸化抗体
■应用领域:	/细胞生物/神经生物学/信号转导/细胞凋亡/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 45kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human p56Dok2 around the phosphorylation site of Tyr299
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化D酪氨酸激酶衰减蛋白2抗体Anti-Phospho-p56Dok2（Tyr299）的相关产品目录：







1mg/1ml 磷酸化D酪氨酸激酶衰减蛋白2抗体 Anti-Phospho-p56Dok2（Tyr299） Docking protein 2 56kDa; Docking protein 2 antibody DOK 2; DOK R; Downstream of tyrosine k的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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