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田源抗体,磷酸化DNA甲基转移酶1抗体,Anti-phospho-Dnmt1(Tyr399),一抗磷酸化抗体 上海 价格
点击次数:154发布时间:2012/7/31 14:16:20
更新日期:2013/4/11 9:54:57
所 在 地:其它
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详细内容
磷酸化DNA甲基转移酶1抗体Anti-phospho-Dnmt1(Tyr399)DNMT1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI;
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化DNA甲基转移酶1抗体
英文名称:Anti-phospho-Dnmt1(Tyr399)
别名:DNMT1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The DNA methyltransferase 1 in various tumor cells the expression measure very high, but then low expression in normally become person's cell, so the high expression of the gene of dnmt1 and the occurrence of the tumors contain close relation. A cells period, propagate and the Apoptosis have certain of of influence.Subcellular Location : Nucleus.Tissue Specificity : Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.Similarity : Belongs to the C5-methyltransferase family.Contains 2 BAH domains.Contains 1 CXXC-type zinc finger.Subunit : Binds to CSNK1D (By similarity). Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5.DNA甲基转移酶-1在多种肿瘤细胞中表达量相当高,而在正常成人细胞中则低表达,因此dnmt1基因的高表达与肿瘤的发生有密切的关系。 dnmt-1 对细胞周期、增殖及凋亡有一定的的影响。细胞核表达。 (isoform CRA_a)为抑制细胞增殖、促进细胞凋亡,为肿瘤的基因治疗提供依据。磷酸化DNA甲基转移酶1抗体的质量标准:
■其它名称: | DNMT1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; |
■交叉反应: | hu, pig, dog, hrs |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/细胞凋亡 |
■蛋白分子: | predicted molecular weight: 186kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human Dnmt1 around the phosphorylation site of Tyr399 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化DNA甲基转移酶1抗体Anti-phospho-Dnmt1(Tyr399)的相关产品目录:
1mg/1ml 磷酸化DNA甲基转移酶1抗体 Anti-phospho-Dnmt1(Tyr399) DNMT1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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