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田源抗体,真核翻译起始因子4E抗体,Anti-eIF4E,一抗 上海 价格
点击次数:142发布时间:2012/7/31 14:18:33
更新日期:2013/4/11 9:54:46
所 在 地:其它
产品型号:
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详细内容
真核翻译起始因子4E抗体Anti-eIF4EEIF4F; eIF-4E; eIF 4E; CBP; eIF 4F 25 kDa subunit; CBP; eIF 4E; eIF 4F 25 kDa subunit; EIF
360TIYO.COM-上海田源公司
性能参数:
中文名称:真核翻译起始因子4E抗体
英文名称:Anti-eIF4E
别名:EIF4F; eIF-4E; eIF 4E; CBP; eIF 4F 25 kDa subunit; CBP; eIF 4E; eIF 4F 25 kDa subunit; EIF
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.真核细胞翻译起始因子4E-EIF4E是蛋白合成的一个主要调控因子,它表达量增加会促进多种肿瘤的生长的增值、分化,因此EIF4E是一种非常重要的抗癌药物靶标。eIF-4E是一种涉及核糖体与mRNA帽子结构结合的真核生物翻译起始因子。它以2种形式存在:游离形式(25kDa)和作为多蛋白复合物eIF-4F的一个组分。 eIF-4E 是数量*少的一种起始因子,涉及翻译起始的限速步骤,磷酸化调节蛋白质的生物合成。真核翻译起始因子4E抗体的质量标准:
■其它名称: | EIF4F; eIF-4E; eIF 4E; CBP; eIF 4F 25 kDa subunit; CBP; eIF 4E; eIF 4F 25 kDa subunit; EIF |
■交叉反应: | hu, mo, rat, dog, pig, hrs, cow, chk, Rb, Danio rerio |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子 |
■蛋白分子: | predicted molecular weight: 25kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human eIF4E |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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真核翻译起始因子4E抗体Anti-eIF4E的相关产品目录:
1mg/1ml 真核翻译起始因子4E抗体 Anti-eIF4E EIF4F; eIF-4E; eIF 4E; CBP; eIF 4F 25 kDa subunit; CBP; eIF 4E; eIF 4F 25 kDa subunit; EIF的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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