磷酸化Disabled 1抗体Anti-Phospho-Dab1 （Tyr220）Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari
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性能参数：

中文名称：磷酸化Disabled 1抗体
英文名称：Anti-Phospho-Dab1 （Tyr220）
别名：Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Disabled 1 （Dab1） is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler ａnd yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects ａnd ataxia, disruption of neuronal migration, ａnd severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding （PTB） domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor （VLDLR） ａnd Apolipoprotein E Receptor 2 （ApoER2） through stimulation of Src family kinases. Src family kinase ａnd c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt （PKB） by reelin resulting in inhibition of glycogen synthase kinase 3 beta （GSK-3 beta） ａnd decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner ａnd regulates, likely indirectly, Reelin-induced signaling during neural cortex development.

磷酸化Disabled 1抗体的质量标准：

■其它名称：	Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari
■交叉反应：	hu, rat, mo
■产品类型：	一抗磷酸化抗体
■应用领域:	/神经生物学
■蛋白分子：	predicted molecular weight: 80kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human Dab1 around the phosphorylation site of Tyr220
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化Disabled 1抗体Anti-Phospho-Dab1 （Tyr220）的相关产品目录：







1mg/1ml 磷酸化Disabled 1抗体 Anti-Phospho-Dab1 （Tyr220） Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

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