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田源抗体,磷酸化粘着斑激酶抗体,Anti-phospho-PTK2(Tyr576+Tyr577),一抗磷酸化抗体 上海 价格
点击次数:107发布时间:2012/8/1 11:41:07
更新日期:2013/4/11 9:21:50
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磷酸化粘着斑激酶抗体Anti-phospho-PTK2(Tyr576+Tyr577)PTK2 (phospho Y576/Y577); FADK 1; FADK; FAK 1; FAK related non kinase polypeptide; FAK1; F
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中文名称:磷酸化粘着斑激酶抗体
英文名称:Anti-phospho-PTK2(Tyr576+Tyr577)
别名:PTK2 (phospho Y576/Y577); FADK 1; FADK; FAK 1; FAK related non kinase polypeptide; FAK1; F
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.Subcellular Location : Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Nucleus. Tissue Specificity : Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.Contains 1 FERM domain.Contains 1 protein kinase domain.FAK是整合蛋白介导的信号转导中的重要成员,有酪氨酸蛋白激酶活性,并可自身磷酸化,FAK本身是胱冬肽酶(caspase)的底物。作为信号分子的FAK参与抑制细胞凋亡并直接参与细胞多种功能的调节。 1.FAK 局部粘着斑激酶,是一种酪氨酸激酶;肿瘤细胞的侵袭性生长是一个多步骤的复杂过程,有多种生物化学因子参与其中,局部粘着斑激酶(focal adhesion kinase, FAK)介导的信号转导系统就是其中*为重要的细胞信号转导途径。肿瘤细胞必须黏附于细胞外基质,通过促进依赖于PTK激酶活性的细胞外基质信号转导,进而影响细胞的黏附、运动与迁移。2.粘着斑激酶(focal adhesion kinase,FAK)是整合蛋白介导的信号转导中的重要成员,有酪氨酸蛋白激酶活性,并可自身磷酸化;为信号分子的FAK,还与细胞内其他信号转导通路存在串话(crosstalk),直接参与了细胞多种功能的调节。 3.尽管FAK的确切功能尚不清楚,但若干实验均提示FAK可能有两个作用,一是在细胞铺展和移动时,FAK参与粘着斑形成和调节;二是FAK参与信号转导过程,以告知细胞核其细胞已锚定了。近年有关FAK在细胞凋亡中的作用也业已肯定。磷酸化粘着斑激酶抗体的质量标准:
■其它名称: | PTK2 (phospho Y576/Y577); FADK 1; FADK; FAK 1; FAK related non kinase polypeptide; FAK1; F |
■交叉反应: | hu, mo, rat, hrs, cow, chk, dog, Rb |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 116kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthesised phosphopeptide derived from human PTK2 around the phosphorylation site of Tyr576+Tyr577 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化粘着斑激酶抗体Anti-phospho-PTK2(Tyr576+Tyr577)的相关产品目录:
1mg/1ml 磷酸化粘着斑激酶抗体 Anti-phospho-PTK2(Tyr576+Tyr577) PTK2 (phospho Y576/Y577); FADK 1; FADK; FAK 1; FAK related non kinase polypeptide; FAK1; F的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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