产品展示
田源抗体,磷酸化载脂蛋白A1抗体,Anti-phospho-FAS (Tyr291),一抗磷酸化抗体 上海 价格
点击次数:149发布时间:2012/8/1 11:42:20
更新日期:2013/4/11 9:21:43
所 在 地:其它
产品型号:
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详细内容
磷酸化载脂蛋白A1抗体Anti-phospho-FAS (Tyr291)CD95; Apo-1; FasL receptor; Tumor necrosis factor receptor superfamily member 6 precursor;
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性能参数:
中文名称:磷酸化载脂蛋白A1抗体
英文名称:Anti-phospho-FAS (Tyr291)
别名:CD95; Apo-1; FasL receptor; Tumor necrosis factor receptor superfamily member 6 precursor;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:FAS is a receptor for TNFSF6/FASL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance of homeostasis in many organisms. This “cellular suicide” can be mediated by the Fas antigen (CD95, APO1), a cell-surface glycoprotein, 40-50kDa, that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). It is type I membrane protein. Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adaptor proteins Contains 1 death domain.FAS的凋亡信号主要是通过与其胞浆区相关的死亡结构域蛋白FADD介导的。FAS与FasL结合后,FADD一方面通过C端的DD结合FAS, 另一方面通过N端的DED与Caspase-8 N端DED结合,通过Caspase-8诱导效应性Caspase 蛋白酶的激活,并*终导致细胞凋亡的发生。FAS主要表达于活化淋巴细胞、单核细胞、中性粒细胞和成纤维细胞等。Fas又称作APO-1/CD95,属TNF受体家族。Fas基因编码产物为分子量45KD的跨膜蛋白,分布于胸腺细胞,激活的T和B淋巴细胞,巨噬细胞,肝、脾、肺、心、脑、肠、睾丸和卵巢细胞等。 Fas蛋白与Fas配体结合后,会激活caspase,导致靶细胞走向凋亡。磷酸化载脂蛋白A1抗体的质量标准:
■其它名称: | CD95; Apo-1; FasL receptor; Tumor necrosis factor receptor superfamily member 6 precursor; |
■交叉反应: | rat, mo |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/细胞凋亡 |
■蛋白分子: | predicted molecular weight: 40-50kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human FAS around the phosphorylation site of Tyr291 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化载脂蛋白A1抗体Anti-phospho-FAS (Tyr291)的相关产品目录:
1mg/1ml 磷酸化载脂蛋白A1抗体 Anti-phospho-FAS (Tyr291) CD95; Apo-1; FasL receptor; Tumor necrosis factor receptor superfamily member 6 precursor;的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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