DNA切除修复蛋白1抗体Anti-ERCC1Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DN
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性能参数：

中文名称：DNA切除修复蛋白1抗体
英文名称：Anti-ERCC1
别名：Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DN
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The product of this gene functions in the nucleotide excision repair pathway, ａnd is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease （also known as ERCC4）, ａnd the heterodimeric endonuclease catalyzes the 5＇ incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair ａnd in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, ａnd polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.Subcellular Location : Nucleus.Similarity : Belongs to the ERCC1/RAD10/SWI10 family.Subunit : Heterodimer composed of ERCC1 ａnd XPF/ERRC4.ERCC1蛋白是动物内重要的DNA修复基因家族成员。在人体内它的低表达往往伴随着基因不稳定性增加,从而产生肿瘤恶性变的发生。ERCC1是损伤DNA核苷酸切除修复中高度保守的切除性核酶。在哺乳动物的核苷酸切除修复中，XPG负责切割DNA损伤区域的3’端，而ERCC1-XPF复合物在5’端打开切口。目前初步的研究表明，癌瘤中的ERCC1蛋白表达程度越低，顺氯氨铂化疗的效果就越好。ERCC1蛋白阳性的患者，非化疗治疗的预后要好于接受化疗。

DNA切除修复蛋白1抗体的质量标准：

■其它名称：	Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DN
■交叉反应：	hu, mo, rat, cow, dog, pig
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学
■蛋白分子：	predicted molecular weight: 36kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human ERCC1
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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DNA切除修复蛋白1抗体Anti-ERCC1的相关产品目录：







1mg/1ml DNA切除修复蛋白1抗体 Anti-ERCC1 Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DN的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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