磷酸化FMS样酪氨酸激酶3Anti-Phospho-FLT3（Tyr591）CD135 antigen; Fetal liver kinase 2; FL cytokine receptor; Flk 2; Flk2; Flt 3; Flt3; FMS
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性能参数：

中文名称：磷酸化FMS样酪氨酸激酶3
英文名称：Anti-Phospho-FLT3（Tyr591）
别名：CD135 antigen; Fetal liver kinase 2; FL cytokine receptor; Flk 2; Flk2; Flt 3; Flt3; FMS
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：CD135 is a tyrosine kinase receptor expressed on normal cells including CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, ａnd thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL ａnd CML BC. CD135, also known as FMS-like tyrosine kinase 3, FLT3, STK1, ａnd Flk2, is a growth factor receptor that binds the FLT3 ligand to promote the growth ａnd differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation ａnd has been shown to interact with Grb2, SOCS1, VAV1, ａnd Shc. In humans, expression of Flt3 is restricted to subsets of CD34 positive as well as CD34 negative normal bone marrow cells. In these cells, the level of expression of Flt3 is rather low. Most of the CD34 bright Flt3+ cells co-express CD117 at high levels. They may represent early cycling, but not quiescent stem cells. Flt3+ cells in the CD34lo ａnd CD34- populations do not co-express CD117 molecule ａnd may represent B lymphoid precursors.Subcellular Location : Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen.Tissue Specificity : Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells ａnd in granulocyte/macrophage progenitor cells （at protein level）. Detected in bone marrow, liver, thymus, spleen ａnd lymph node, ａnd at low levels in kidney ａnd pancreas. Highly expressed in T-cell leukemia.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 1 Ig-like C2-type （immunoglobulin-like） domain.Contains 1 protein kinase domain.Subunit : Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. One homodimer interacts with one FLT3LG molecule. Interacts with FIZ1 following ligand activation （By similarity）. Interacts with FES, FER ａnd GRB2. Interacts with PTPRJ/DEP-1 ａnd PTPN11/SHP2.

磷酸化FMS样酪氨酸激酶3的质量标准：

■其它名称：	CD135 antigen; Fetal liver kinase 2; FL cytokine receptor; Flk 2; Flk2; Flt 3; Flt3; FMS
■交叉反应：	hu, mo
■产品类型：	一抗磷酸化抗体
■应用领域:	/信号转导/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 109kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr591
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化FMS样酪氨酸激酶3Anti-Phospho-FLT3（Tyr591）的相关产品目录：







1mg/1ml 磷酸化FMS样酪氨酸激酶3 Anti-Phospho-FLT3（Tyr591） CD135 antigen; Fetal liver kinase 2; FL cytokine receptor; Flk 2; Flk2; Flt 3; Flt3; FMS 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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