丝裂原活化蛋白激酶磷酸酶-2抗体Anti-MKP-2/DUSP4Mitogen activated protein kinase phosphatase 2; Dual specificity phosphatase 4; Dual spec
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性能参数：

中文名称：丝裂原活化蛋白激酶磷酸酶-2抗体
英文名称：Anti-MKP-2/DUSP4
别名：Mitogen activated protein kinase phosphatase 2; Dual specificity phosphatase 4; Dual spec
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine ａnd phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein （MAP） kinase superfamily （MAPK/ERK, SAPK/JNK, p38）, which is associated with cellular proliferation ａnd differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution ａnd subcellular localization, ａnd different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 ａnd JNK, is expressed in a variety of tissues, ａnd is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.Subcellular Location : Nucleus.Similarity : Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Contains 1 rhodanese domain.Contains 1 tyrosine-protein phosphatase domain.Subunit : Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic unit.MKPs是一类丝氨酸/苏氨酸和酪氨酸双重底物特异性的磷酸酶 ,对于丝裂素活化蛋白激酶活性的调节起着十分重要的作用，可使丝裂素活化蛋白激酶上的苏氨酸/酪氨酸去磷酸化失活。目前研究发现MKPs分别有MKP-1、MKP-2、MKP-3及MKP4-6。MKPs受MAPK信号通路中多种成分的诱导 ,决定了它与MAPK之间作用的特异性。 通过去磷酸化作用调节MAPK信号途径的活性 ,确保了细胞内信号的精确传递 ,参与了多种主要的细胞功能的调节。

丝裂原活化蛋白激酶磷酸酶-2抗体的质量标准：

■其它名称：	Mitogen activated protein kinase phosphatase 2; Dual specificity phosphatase 4; Dual spec
■交叉反应：	hu, mo, rat, Rb, cow, chk, dog
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/信号转导
■蛋白分子：	predicted molecular weight: 44kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human MKP-2 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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丝裂原活化蛋白激酶磷酸酶-2抗体Anti-MKP-2/DUSP4的相关产品目录：







1mg/1ml 丝裂原活化蛋白激酶磷酸酶-2抗体 Anti-MKP-2/DUSP4 Mitogen activated protein kinase phosphatase 2; Dual specificity phosphatase 4; Dual spec的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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