红细胞生成素受体抗体Anti-EPORerythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
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性能参数：

中文名称：红细胞生成素受体抗体
英文名称：Anti-EPOR
别名：erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The erythropoietin receptor （EPOR） is a member of the cytokine receptor family. There are several isoforms including: EPOR-F （full length）, EPOR-S （soluble form）, ａnd EPOR-T （truncated form）. Upon erythropoietin （EPO） binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase ａnd STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia ａnd familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells ａnd cardiomyocytes, ａnd data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size ａnd the extent of apoptosis.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Isoform EPOR-S: Secreted. Note=Secreted ａnd located to the cell surface.Tissue Specificity : Erythroid cells ａnd erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells ａnd in late-stage erythroid progenitors. Isoform EPOR-S ａnd isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells.Similarity : Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain.Subunit : Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL. Interacts with INPP5D/SHIP1. The N-terminal SH2 domain of PTPN6 binds Tyr-454 ａnd inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis ａnd phosphorylation of PTPN11. Binding of JAK2 （through its N-terminal） promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L.

红细胞生成素受体抗体的质量标准：

■其它名称：	erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
■交叉反应：	hu, mo, rat, hrs, cow, dog
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学
■蛋白分子：	predicted molecular weight: 56kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human EPOR C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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红细胞生成素受体抗体Anti-EPOR的相关产品目录：







1mg/1ml 红细胞生成素受体抗体 Anti-EPOR erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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