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田源抗体,磷酸化丝裂原活化蛋白激酶磷酸酶-1抗体,Anti-Phospho-MKP1 (Ser359),一抗磷酸化抗体 上海 价格
点击次数:147发布时间:2012/8/1 11:48:10
更新日期:2013/3/22 10:49:54
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详细内容
磷酸化丝裂原活化蛋白激酶磷酸酶-1抗体Anti-Phospho-MKP1 (Ser359)Mitogen activated protein kinase phosphatase 1; CL 100; CL100; Dual Specificity Phosphatas
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性能参数:
中文名称:磷酸化丝裂原活化蛋白激酶磷酸酶-1抗体
英文名称:Anti-Phospho-MKP1 (Ser359)
别名:Mitogen activated protein kinase phosphatase 1; CL 100; CL100; Dual Specificity Phosphatas
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Tissue Specificity : Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.Similarity : Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Contains 1 rhodanese domain.Contains 1 tyrosine-protein phosphatase domain.MKPs是一类丝氨酸/苏氨酸和酪氨酸双重底物特异性的磷酸酶 ,对于丝裂素活化蛋白激酶活性的调节起着十分重要的作用,可使丝裂素活化蛋白激酶上的苏氨酸/酪氨酸去磷酸化失活。目前研究发现MKPs分别有MKP-1、MKP-2、MKP-3及MKP4-6。MKPs受MAPK信号通路中多种成分的诱导 ,决定了它与MAPK之间作用的特异性。 通过去磷酸化作用调节MAPK信号途径的活性 ,确保了细胞内信号的精确传递 ,参与了多种主要的细胞功能的调节。磷酸化丝裂原活化蛋白激酶磷酸酶-1抗体的质量标准:
■其它名称: | Mitogen activated protein kinase phosphatase 1; CL 100; CL100; Dual Specificity Phosphatas |
■交叉反应: | hu, rat, mo |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 40kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthesised phosphopeptide derived from human MKP1 around the phosphorylation site of Ser359 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化丝裂原活化蛋白激酶磷酸酶-1抗体Anti-Phospho-MKP1 (Ser359)的相关产品目录:
1mg/1ml 磷酸化丝裂原活化蛋白激酶磷酸酶-1抗体 Anti-Phospho-MKP1 (Ser359) Mitogen activated protein kinase phosphatase 1; CL 100; CL100; Dual Specificity Phosphatas的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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