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G蛋白/鸟苷酸结合蛋白抗体Anti-G protein beta subunit GIG protein beta subunit GI/GS/GT; guanine nucleotide binding protein (G protein), beta poly
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中文名称:G蛋白/鸟苷酸结合蛋白抗体
英文名称:Anti-G protein beta subunit GI
别名:G protein beta subunit GI/GS/GT; guanine nucleotide binding protein (G protein), beta poly
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:G protein beta subunit GI/GS/GT (guanine nucleotide-binding protein G). WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. G蛋白又称:鸟苷酸结合蛋白,存在于全身各个组织和细胞中,G蛋白在信息传递中起到很重要的作用,参与细胞内外信息的相互传导。 激素受体与腺苷酸环化酶是细胞膜上两类分开的蛋白质。激素受体结合的部分在细胞膜的外表面,而腺苷环化酶在膜的胞浆面,在两者之间存在一种起耦联作用的调节蛋白——鸟苷酸结合蛋白(guanine nucleotide-binding regulatory protein)细胞受到各种刺激信息,包括化学性的激素和神经递质及非化学性的声音、图像等。刺激信息通过G蛋白的激活作用,在胞浆中生成数目众多的第二信使分子,产生十万级放大效应,引起细胞兴奋,让后促动器官完成各自功能。1977年,美国科学家阿尔弗雷德-戈德曼-吉尔曼(Alfred Goodman Gilman)发现了G蛋白及其在细胞兴奋传导方面的重要作用。1994年,吉尔曼因“G蛋白”方面的研究成果而荣获诺贝尔生理及医学奖。G蛋白/鸟苷酸结合蛋白抗体的质量标准:
■其它名称: | G protein beta subunit GI/GS/GT; guanine nucleotide binding protein (G protein), beta poly |
■交叉反应: | hu |
■产品类型: | 一抗 |
■应用领域: | /细胞生物/免疫学/神经生物学 |
■蛋白分子: | predicted molecular weight: 38kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human G protein beta subunit GI C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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G蛋白/鸟苷酸结合蛋白抗体Anti-G protein beta subunit GI的相关产品目录:
1mg/1ml G蛋白/鸟苷酸结合蛋白抗体 Anti-G protein beta subunit GI G protein beta subunit GI/GS/GT; guanine nucleotide binding protein (G protein), beta poly的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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