产品展示
田源抗体,载脂蛋白A1抗体,Anti-FAS/Apo-1/CD95,一抗 上海 价格
点击次数:139发布时间:2012/8/1 11:50:05
更新日期:2013/3/22 10:45:30
所 在 地:其它
产品型号:
优质供应
详细内容
载脂蛋白A1抗体Anti-FAS/Apo-1/CD95CD95; Apo-1; SFAS; FasL receptor; Tumor necrosis factor receptor superfamily member 6 prec
360TIYO.COM-上海田源公司
性能参数:
中文名称:载脂蛋白A1抗体
英文名称:Anti-FAS/Apo-1/CD95
别名:CD95; Apo-1; SFAS; FasL receptor; Tumor necrosis factor receptor superfamily member 6 prec
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
----------------------------------------------------------
产品详细描述
产品介绍:FAS is a receptor for TNFSF6/FASL. The adaptor molecule FADDrecruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance of homeostasis in many organisms. This “cellular suicide” can be mediated by the Fas antigen (CD95, APO1), a cell-surface glycoprotein, 40-50kDa, that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). It is type I membrane protein. Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adaptor proteins Contains 1 death domain.FAS(也称作Apo-1;CD95;FasL receptor;TNFR)是一个含有死亡结构域的受体,是一型膜蛋白,属于TNF-R家族成员,具有诱导细胞凋亡的功能,广泛分布于许多不同类型的细胞,主要用于各种恶性肿瘤(包括:乳腺癌、肾细胞癌、胃癌、肺癌以及肝病等)的研究。分子量为:40-50kDa。 FAS的凋亡信号主要是通过与其胞浆区相关的死亡结构域蛋白FADD介导的。FAS与FasL结合后,FADD一方面通过C端的DD结合FAS, 另一方面通过N端的DED与Caspase-8 N端DED结合,通过Caspase-8诱导效应性Caspase 蛋白酶的激活,并*终导致细胞凋亡的发生。FAS主要表达于活化淋巴细胞、单核细胞、中性粒细胞和成纤维细胞等。 Fas又称作APO-1/CD95,属TNF受体家族。Fas基因编码产物为分子量45KD的跨膜蛋白,分布于胸腺细胞,激活的T和B淋巴细胞,巨噬细胞,肝、脾、肺、心、脑、肠、睾丸和卵巢细胞等。 Fas蛋白与Fas配体结合后,会激活caspase,导致靶细胞走向凋亡。载脂蛋白A1抗体的质量标准:
■其它名称: | CD95; Apo-1; SFAS; FasL receptor; Tumor necrosis factor receptor superfamily member 6 prec |
■交叉反应: | rat, mo |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/免疫学/细胞凋亡 |
■蛋白分子: | predicted molecular weight: 40-50kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human FAS |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
----------------------------------------------------------
质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。
友情提醒:
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性,恕不接受以下投诉:
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉
载脂蛋白A1抗体Anti-FAS/Apo-1/CD95的相关产品目录:
1mg/1ml 载脂蛋白A1抗体 Anti-FAS/Apo-1/CD95 CD95; Apo-1; SFAS; FasL receptor; Tumor necrosis factor receptor superfamily member 6 prec的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
查询其它抗体目录请点击本公司化工仪器网链接:http://www.chem17.com/st233816/erlist_675408.html
上海田源专业销售载脂蛋白A1抗体 Anti-FAS/Apo-1/CD95,了解更多请点击查询!