酪氨酸蛋白激酶A4抗体Anti-EphA4Ephrin receptor ligand binding domain; TYRO1; Cek 8 ; EphA4; Ephrin receptor Eph A4; Ephri
360TIYO.COM-上海田源公司

性能参数：

中文名称：酪氨酸蛋白激酶A4抗体
英文名称：Anti-EphA4
别名：Ephrin receptor ligand binding domain; TYRO1; Cek 8 ; EphA4; Ephrin receptor Eph A4; Ephri
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

产品详细描述

产品介绍：Eph receptor A4 is a receptor for members of the ephrin-A family. It binds to ephrin-A1, -A4 ａnd -A5 but binds more poorly to ephrin-A2 ａnd -A3. Eph receptor A4 may play a role in a signal transduction process involved in hindbrain pattern formation. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement ａnd cell movement, apoptosis, ａnd differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine （PTK） or serine/threonine （STK） kinase catalytic domains. The tyrosine kinase （TK） group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility ａnd death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK （e.g. EGFR, EPH, FGFR, PDGFR, TRK, ａnd VEGFR families）, ａnd 32 of cytosolic TK （e.g. ABL, FAK, JAK, ａnd SRC families）.Subcellular Location : Cell membrane; Single-pass type I membrane protein （By similarity）. Cell projection, axon （By similarity）. Cell projection, dendrite （By similarity）. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density （By similarity）. Early endosome （By similarity）. Note=Clustered upon activation ａnd targeted to early endosome （By similarity）.Tissue Specificity : Ubiquitous.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 1 Eph LBD （Eph ligand-binding） domain. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain.Contains 1 SAM （sterile alpha motif） domain.Subunit : Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer ａnd a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts （phosphorylated at position Tyr-602） with FYN. Interacts with CDK5, CDK5R1 ａnd NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation （By similarity）. Interacts （via PDZ motif） with SIPA1L1 （via PDZ domain）; controls neuronal morphology through regulation of the RAP1 （RAP1A or RAP1B） ａnd RAP2 （RAP2A, RAP2B or RAP2C） GTPases.

酪氨酸蛋白激酶A4抗体的质量标准：

■其它名称：	Ephrin receptor ligand binding domain; TYRO1; Cek 8 ; EphA4; Ephrin receptor Eph A4; Ephri
■交叉反应：	hu, mo, rat, Rb, pig, hrs, dog, chk
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 108kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human EphA4 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。

友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

酪氨酸蛋白激酶A4抗体Anti-EphA4的相关产品目录：







1mg/1ml 酪氨酸蛋白激酶A4抗体 Anti-EphA4 Ephrin receptor ligand binding domain; TYRO1; Cek 8 ; EphA4; Ephrin receptor Eph A4; Ephri的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

上海田源专业销售酪氨酸蛋白激酶A4抗体 Anti-EphA4，了解更多请点击查询！