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G氨基丁酸B型受体2抗体 Anti-GABBR2/GB2 田源一抗
点击次数:133发布时间:2012/8/2 11:29:08
更新日期:2013/3/22 10:34:14
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详细内容
G氨基丁酸B型受体2抗体Anti-GABBR2/GB2gamma-aminobutyric acid (GABA) B receptor 2; Gamma-aminobutyric acid type B receptor subun
360TIYO.COM-上海田源公司
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中文名称:G氨基丁酸B型受体2抗体
英文名称:Anti-GABBR2/GB2
别名:gamma-aminobutyric acid (GABA) B receptor 2; Gamma-aminobutyric acid type B receptor subun
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.g-氨基丁酸(GABA)是哺乳动物中枢神经系统中重要的抑制性神经递质,在体内通过作用于离子通道型的GABAA、GABAC受体及代谢型的GABAB受体而发挥生理功能。 GABAB 受体存在于神经元的突触前及突触后部位,介导慢的抑制性效应,在脑内参与许多重要的生理活动和病理变化,包括认知损害、癫痫、痉挛及药物成瘾等。 GABAB2在与GABAB1形成二聚体后可激活G蛋白,但它没有结合GABA的能力;GABAB2还可增强激动剂与GABAB1的亲和力,并且通过与GABAB1形成二聚体结构而屏蔽GABAB1的胞内滞留信号。G氨基丁酸B型受体2抗体的质量标准:
■其它名称: | gamma-aminobutyric acid (GABA) B receptor 2; Gamma-aminobutyric acid type B receptor subun |
■交叉反应: | hu, mo, rat, cow, hrs, Rb, dog, chk |
■产品类型: | 一抗 |
■应用领域: | /免疫学/神经生物学 |
■蛋白分子: | predicted molecular weight: 103kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human GABABR2 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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G氨基丁酸B型受体2抗体Anti-GABBR2/GB2的相关产品目录:
1mg/1ml G氨基丁酸B型受体2抗体 Anti-GABBR2/GB2 gamma-aminobutyric acid (GABA) B receptor 2; Gamma-aminobutyric acid type B receptor subun的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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