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葡萄糖调节蛋白94抗体 田源一抗
点击次数:167发布时间:2012/8/3 17:48:58
更新日期:2013/5/3 14:36:48
所 在 地:其它
产品型号:Anti-GRP94/gp96
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详细内容
葡萄糖调节蛋白94抗体Anti-GRP94/gp9694 kDa glucose regulated protein; ECGP; Endoplasmin; Endothelial cell (HBMEC) glycoprotein
360TIYO.COM-上海田源公司
性能参数:
中文名称:葡萄糖调节蛋白94抗体
英文名称:Anti-GRP94/gp96
别名:94 kDa glucose regulated protein; ECGP; Endoplasmin; Endothelial cell (HBMEC) glycoprotein
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:Glucose regulated protein 94 (GRP 94) is a resident protein of the endoplasmic reticulum (ER) and is induced by the accumulation of unfolded proteins suggesting that it might associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP 94 and other resident ER proteins including GRP 78 and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. GRP 94 is also a low affinity, high capacity calcium binding protein, though it's role, if any, in calcium regulation is not understood. 信号传导(Signaling Intermediates) GRP94(G蛋白偶联受体94)蛋白又称GP96属于热休克蛋白90家组成员。由二硫键连接的同源二具体表达在内质网腔。内质网分子伴侣Grp94在正常细胞的内质网腔中含量较高,Grp94在内质网生成、并存留在内质网中,其表达与多种因素有关,各种应激条件下可见其表达明显增高。细胞周期也是常见的影响细胞增殖的因素,因此细胞增殖过程中Grp94的表达情况具有重要意义。Grp94与细胞周期有关。葡萄糖调节蛋白94抗体的质量标准:
■其它名称: | 94 kDa glucose regulated protein; ECGP; Endoplasmin; Endothelial cell (HBMEC) glycoprotein |
■交叉反应: | hu, rat, mo, Rb, pig, dog, cow, hrs., chk |
■产品类型: | 一抗 |
■应用领域: | /细胞生物/免疫学/神经生物学/信号转导/细胞凋亡 |
■蛋白分子: | predicted molecular weight: 94kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human GRP94 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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葡萄糖调节蛋白94抗体Anti-GRP94/gp96的相关产品目录:
1mg/1ml 葡萄糖调节蛋白94抗体 Anti-GRP94/gp96 94 kDa glucose regulated protein; ECGP; Endoplasmin; Endothelial cell (HBMEC) glycoprotein的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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